Results 81 to 90 of about 1,470,777 (390)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Adaptability evaluation of the software for transient process simulation of supercritical CO2 pipelines

You-qi chuyun
Objective Transient processes like leakage and commissioning in CO2 pipeline operation pose simulation challenges due to the unique physical properties and phase behavior of CO2.
Xinyuan MA, Xin OUYANG, Jianlu ZHU, Junwen CHEN, Luoqian LIU, Teng YANG, Guangchun SONG   +6 more
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Research on leakage hazards of embankments based on 3D electrical resistivity tomography technology

Građevinar
Leakage is a common issue in reservoirs; however, accurately detecting its location and seepage diameter can be challenging owing to complex geological conditions.
Yuehang Zhao, Risheng Wang, Tao Gao, Tao Guo, Xin Guo   +4 more
doaj   +1 more source

Predictive factors for anastomotic leakage after laparoscopic colorectal surgery

World Journal of Gastroenterology, 2018
Every colorectal surgeon during his or her career is faced with anastomotic leakage (AL); one of the most dreaded complications following any type of gastrointestinal anastomosis due to increased risk of morbidity, mortality, overall impact on functional
A. Sciuto, G. Merola, G. D. De Palma, M. Sodo, F. Pirozzi, U. Bracale, U. Bracale   +6 more
semanticscholar   +1 more source

Information Leakage Games

, 2017
We consider a game-theoretic setting to model the interplay between attacker and defender in the context of information flow, and to reason about their optimal strategies.
A Matsui, A Nedić, A Rubinstein, C Dwork, CE Shannon, D Chaum, D Clark, D Korzhyk, G Smith, J Neumann Von, K Chatzikokolakis, M Boreale, M Yang, MH Manshaei, MJ Osborne, MK Reiter, N Alon, P Venkitasubramaniam, S Boyd, S Farhang   +19 more
core   +2 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

SafeSpec: Banishing the Spectre of a Meltdown with Leakage-Free Speculation [PDF]

Design Automation Conference, 2018
Speculative attacks, such as Spectre and Meltdown, target speculative execution to access privileged data and leak it through a side-channel. In this paper, we introduce (SafeSpec), a new model for supporting speculation in a way that is immune to the ...
Khaled N. Khasawneh, Esmaeil Mohammadian Koruyeh, Chengyu Song, Dmitry Evtyushkin, D. Ponomarev, N. Abu-Ghazaleh   +5 more
semanticscholar   +1 more source

The Influence of Swirl Brakes on the Rotordynamic Forces Generated by Discharge-to-Suction Leakage Flows in Centrifugal Pumps [PDF]

, 1993
Increasing interest has been give to swirl brakes as a means of reducing destabilizing rotordynamic forces due to leakage flows in new high speed rocket turbopumps.
Acosta, Allan J., Brennen, Christopher E., Caughey, Thomas K., Sivo, Joseph M.   +3 more
core