Results 31 to 40 of about 63,259 (259)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Numerical simulation on the effect of ambient temperature on leakage and diffusion of LNG

You-qi chuyun, 2021
The difference of vapor cloud density and the variation of atmospheric turbulence caused by ambient temperature are the main factors influencing the leakage and diffusion of LNG.
Ning ZHOU, Li CHEN, Xiaofei LYU, Xue LI, Weiqiu HUANG, Huijun ZHAO, Xuanya LIU   +6 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Research progress on characteristics of leakage and diffusion of buried CO2 pipeline

You-qi chuyun
Objective CO2 pipeline transmission, a key link in the industrial chain of carbon capture, utilization, and storage (CCUS) technology, is exposed to risks of accidental leakage during operation.
Junpeng ZHANG, Qing MIAO, Shaodong JING, Yongsheng WANG, Xin OUYANG, Zhenning FAN, Haining LIANG, Jian ZHANG   +7 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Research on Hydrogen Leakage Risk Control Methods in Deck Compartments of Hydrogen Fuel Cell-Powered Ships Based on CFD Simulation and Ventilation Optimization

Fire
Hydrogen fuel cell vessels represent a vital direction for green shipping, but the risk of large-scale hydrogen leakage and diffusion in their enclosed compartments is particularly prominent. To enhance safety, a simplified three-dimensional model of the
Xiaoyu Liu, Jie Zhu, Zhongcheng Wang, Zhenqiang Fu, Meirong Liu   +4 more
doaj   +1 more source

Leaky Diffusion: Attribute Leakage in Text-Guided Image Generation

Proceedings on Privacy Enhancing Technologies
Text-guided diffusion models can be used to generate photorealistic images conditioned on natural language instructions. Due to their ease of use, millions of users already leverage them to generate and populate images online. In this work, we reveal the risk of attribute (authorship and dementia) leakage from such models.
Lepipas, Anastasios, Charalambides, Marios, Liu, Jiani, Guan, Yiying, Woszczyk, Dominika, -, Mansi, Le, Thanh Hai, Demetriou, Soteris   +7 more
openaire   +2 more sources

PATTERN FORMATION IN REACTION-DIFFUSION NEURAL NETWORKS WITH LEAKAGE DELAY

Journal of Applied Analysis & Computation, 2019
Summary: Due to the heterogeneity of the electromagnetic field in neural networks, the diffusion phenomenon of electrons exists inevitably. In this paper, we investigate pattern formation in a reaction-diffusion neural network with leakage delay.
Lin, Jiazhe, Xu, Rui, Tian, Xiaohong
openaire   +2 more sources