Results 51 to 60 of about 202,557 (336)

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

Leakage diffusion law of hydrogen-mixed natural gas pipeline and layout plan of detectors

You-qi chuyun, 2022
In order to study the change of gas leakage behavior caused by hydrogen mixing and rapidly realize the leakage detection of hydrogen-mixed gas, a plane leakage model for specific semi-closed places was established with the Fluent software, and thereby ...
Qi SUN, Feng LI, Yiwei WANG, Shaohua DONG, Lin CHEN, Hang ZHANG   +5 more
doaj   +1 more source

PATTERN FORMATION IN REACTION-DIFFUSION NEURAL NETWORKS WITH LEAKAGE DELAY

Journal of Applied Analysis & Computation, 2019
Summary: Due to the heterogeneity of the electromagnetic field in neural networks, the diffusion phenomenon of electrons exists inevitably. In this paper, we investigate pattern formation in a reaction-diffusion neural network with leakage delay.
Lin, Jiazhe, Xu, Rui, Tian, Xiaohong
openaire   +2 more sources

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source

Research on Natural Gas Leakage and Explosion Mechanisms in a Container House

Buildings
As unconventional building structures, container houses are now widely used in urban tourism to create characteristic buildings. Nowadays, natural gas accidents occur frequently in cities and towns; however, the development of laws and influencing ...
Yonghong Gao, Yapeng Duan, Runmei Fu, Hao Wu, Zicong Wang, Dongyang Li, Liqiang Zhou   +6 more
doaj   +1 more source

Atmospheric diffusion study of surface leakage from CO2 enhanced oil recovery with carbon capture and storage based on flux monitoring-CFD simulation [PDF]

Youqicang pingjia yu kaifa
CO2 enhanced oil recovery（EOR） with carbon capture and storage（CCS） projects offer dual benefits of increasing oil recovery and CO2 storage, making it one of the most economically viable carbon sequestration methods nowadays.
QU Changqing, LIN Qianguo
doaj   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Research on Hydrogen Leakage Risk Control Methods in Deck Compartments of Hydrogen Fuel Cell-Powered Ships Based on CFD Simulation and Ventilation Optimization

Fire
Hydrogen fuel cell vessels represent a vital direction for green shipping, but the risk of large-scale hydrogen leakage and diffusion in their enclosed compartments is particularly prominent. To enhance safety, a simplified three-dimensional model of the
Xiaoyu Liu, Jie Zhu, Zhongcheng Wang, Zhenqiang Fu, Meirong Liu   +4 more
doaj   +1 more source

Physical analysis of self-discharge mechanism for supercapacitor electrode for hybrid electric energy storage system

Green Energy and Intelligent Transportation, 2023
Self-discharge is a spontaneous process that has considerable adverse effects on the performance of supercapacitors. In order to quantitatively investigate the contribution of self-discharge mechanism, this paper proposed a theoretical self-discharge ...
Weinan Zhao, Zhengxing Zuo, Muhammad Hamza, Boru Jia, Huihua Feng, Bing-Ang Mei   +5 more
doaj   +1 more source

CAR T‐Cell Therapy in Neurology: A Scoping Review of Neuro‐Oncology, Autoimmune Diseases & Neurotoxicity

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Chimeric antigen receptor (CAR) T‐cell therapy has been investigated in neurological diseases, encompassing both central nervous system malignancies and autoimmune disorders, thereby extending its application beyond hematological cancers.
Omar Alqaisi, Mohammed Dibas, Patricia Tai, Ala Dibas, Osama Souied, Suhair Al‐Ghabeesh   +5 more
wiley   +1 more source