Results 41 to 50 of about 154,658 (263)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Optimization Design and Analysis of Supersonic Tandem Rotor Blades
Energies, 2020 To explore the flow mechanism and improve the performance of supersonic tandem rotor blades, the supersonic rotor Rotor37 is taken as the prototype and redesigned to an original supersonic tandem rotor.
Ruochi Pan, Zhaoyun Song, Bo Liu
doaj +1 more source
Sensors, 2021 This paper presents a new universal programmable portable measuring device (PMD) as a complete, accurate, and efficient solution for monitoring and technical diagnostics of industrial fluid power systems.
Ryszard Dindorf, Piotr Wos
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Vibrations in Leaking Spherical Valves with Annular Seal
Proceedings, 2018 Hydroelectric power plants are used worldwide to cover varying electricity demands. The Salime hydroelectric power plant, which is located at Asturias, Spain, has four hydro turbines with a total design capacity of 128 MW.
Hesham Awad +2 more
doaj +1 more source
Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity
FEBS Open Bio, EarlyView.Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz +9 more
wiley +1 more source
Acoustic leak detection technology for multiphase flow pipeline
You-qi chuyun, 2020 At present, the multiphase flow technology is applied increasingly in oil and gas mixed transportation system.However, the safety problems of multiphase pipeline are much more complicated than that of single-phase pipeline. Acousticsensing technology has
Jian JI +4 more
doaj +1 more source
Characterization of Unsteady Leakage Flow in an Axial Fan
International Journal of Turbomachinery, Propulsion and Power, 2023 The present work reports an experimental study of the leakage flow in a low-speed fan ring. Existing 2D Particle Image Velocimetry (PIV) measurements taken in a meridional plane in front of the rotor gap have been further processed and analyzed by means ...
Matteo Dellacasagrande +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.This research protocol outlines a workflow for nuclear magnetic resonance (NMR)‐based metabolomics in the agri‐food sector. Using two case studies—strawberry leaves (solid matrix) and wine (liquid matrix)—it details the procedures for sample preparation, data acquisition, and processing.
Andrea Fernández‐Veloso +4 more
wiley +1 more source
Hydraulic Analysis of Leakage from Submarine Pipe Network
Polish Maritime Research, 2015 The leakage from submarine pipe network is investigated by a numerical model in this paper. A whole event including of the steady flow before the leakage, the transient flow during the leakage and the steady flow after the leakage is considered in the ...
Li JunHua, Fan YanTing
doaj +1 more source