Results 41 to 50 of about 176,939 (311)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Performance Back-deduction from a Loading to Flow Coefficient Map: Application to Radial Turbine [PDF]
, 2012 Radial turbine stages are often used for applications requiring off-design operation, as turbocharging for instance. The off-design ability of such stages is commonly analyzed through the traditional turbine map, plotting the reduced mass-flow against ...
Binder, Nicolas, Carbonneau, Xavier
core +1 more source
LubricantsThe gap seal ring is a critical component in high-speed centrifugal pumps. The leakage rate and performance of the pump are sensitive to variation in seal ring parameters.
Guodong Zhao +4 more
doaj +1 more source
Optimization Design and Analysis of Supersonic Tandem Rotor Blades
Energies, 2020 To explore the flow mechanism and improve the performance of supersonic tandem rotor blades, the supersonic rotor Rotor37 is taken as the prototype and redesigned to an original supersonic tandem rotor.
Ruochi Pan, Zhaoyun Song, Bo Liu
doaj +1 more source
Fluid Flow Equations for Rotordynamic Flows in Seals and Leakage Paths [PDF]
Journal of Fluids Engineering, 2001 Fluid-induced rotordynamic forces produced by the fluid in an annular seal or in the leakage passage surrounding the shroud of a pump or turbine, are known to contribute substantially to the potential excitation forces acting on the rotor. The present research explores some of the important features of the equations governing bulk-flow models of these ...
Hsu, Y., Brennen, C. E.
openaire +2 more sources
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Vibrations in Leaking Spherical Valves with Annular Seal
Proceedings, 2018 Hydroelectric power plants are used worldwide to cover varying electricity demands. The Salime hydroelectric power plant, which is located at Asturias, Spain, has four hydro turbines with a total design capacity of 128 MW.
Hesham Awad +2 more
doaj +1 more source
Elektrika, 2020 The purpose of this research is to design and realize a pipe leak detection system that can be monitored with an Android application. Water flow sensor is used to determine the flow of water, with water flow rate analysis it is possible to know the ...
Ardi DwI Prasetya +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source