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Zinc Supplementation Tightens “Leaky Gut” in Crohn’s Disease
Inflammatory Bowel Diseases, 2001Small intestinal permeability is often increased in patients with Crohn's disease and may be pathogenic for clinical relapses. No effective prophylactic treatment is available for these patients. The aim of this study was to ascertain whether zinc supplementation may improve intestinal permeability.We studied 12 patients with quiescent Crohn's disease ...
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Leaky Gut, Microbiota, and Cancer
Journal of Clinical Gastroenterology, 2014Multigenic disease development is dependent on both missing and overactivated pathways, just as the homeostasis of our body systems is the product of many complex, redundant mechanisms. The goal of finding a common factor in the disease pathogenesis is difficult, as genetic and pathophysiological data are still incomplete, and the individual ...
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Intestinal permeability, leaky gut, and intestinal disorders
Current Gastroenterology Reports, 1999A major task of the intestine is to form a defensive barrier to prevent absorption of damaging substances from the external environment. This protective function of the intestinal mucosa is called permeability. Clinicians can use inert, nonmetabolized sugars such as mannitol, rhamnose, or lactulose to measure the permeability barrier or the degree of ...
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Leaky gut, clotting, and vasculopathy in SIV
Blood, 2012In this issue of Blood, Pandrea et al provide a mechanistic link between SIV-associated microbial translocation and both thrombotic and cardiovascular disease in the pigtail macaque model.
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Metabolic syndrome, leaky guts, and infection
Science, 2018Infection Metabolic syndrome often accompanies obesity and hyperglycemia and is associated with a breakdown in the integrity of the intestinal barrier and increased risk of systemic infection. Thaiss et al. found that mice with systemic infection of a Salmonella analog, Citrobacter rodentium , also exhibited hyperglycemia.
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