Results 91 to 100 of about 325,268 (268)
A Lean Workflow Index for Construction Projects
, 2014 Traditional monitoring methods for construction project control based on the earned-value method provide measures of cash flow and schedule compliance. However, they do not tell managers anything about the quality (stability, continuity) of the workflow,
Seppänen, Olli +8 more
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Avaliação qualitativa da utilização de práticas do lean manufacturing: estudo de caso em uma indústria de utensílios domésticos em alumínio e ferro fundido que não possui um sistema lean estruturado [PDF]
, 2018 This work presents a qualitative assessment of the use of Lean Manufacturing techniques in a housewares industry, aluminium and cast iron that does not have a Lean system implemented in Southwest of Paraná.
Vieira, Everton Luiz +2 more
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
A study about the relationship between lean implementation and psychophysical demands in productive areas [PDF]
, 2018 The growing market competition demands a continuous search for improvements in business processes and their costs. During a long time, organizations have been implementing lean practices to achieve their goals with maximum efficiency and efficacy.
Mazuco da Silva, Isabelly
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Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Principles of the lean construction on the planning process of a huge builder in Natal (RN) [PDF]
, 2016 The civil construction represents one of the most important sectors for the economic growth of a country. To make this industry grow it is necessary to implement an effective planning in activities.
Furukava, Marciano +4 more
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