Results 81 to 90 of about 449,850 (290)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Stability of Micro-Milling Tool Considering Tool Breakage

open access: yesJournal of Manufacturing and Materials Processing
Micro-milling, widely employed across various fields, faces significant challenges due to the small diameter and limited stiffness of its tools, making the process highly susceptible to cutting chatter and premature tool breakage.
Yuan-Yuan Ren   +3 more
doaj   +1 more source

The microbiome in human skin aging

open access: yesFEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana   +3 more
wiley   +1 more source

The precast construction industry and lean construction tools: flow-based management strategy [PDF]

open access: yes, 2022
: The Toyota Production System (TPS) formulated the referential base for the elaboration of lean construction principles, called Lean Construction and organized by Lauri Koskela, in 1992.
Riffel, Elias
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Cultural Development of Mathematical Ideas: Papua New Guinea Studies

open access: yesJournal of Pacific Rim Psychology, 2013
This review highlights the strengths of Geoffrey Saxe's latest book on cultural development of mathematical ideas. His research was undertaken in a remote area of Papua New Guinea. This book is important for it brings together Saxe's critical thinking on
Kay Owens
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

LEAN TOOLS APPLIED IN TRANSPORT AND LOGISTICS SERVICES

open access: yesRevista Produção e Desenvolvimento, 2019
Purpose: This article is focused on the premise that applying Lean tools in transport and logistic services can contribute to reduce the costs, stocks, lead time and simultaneously contributing to major financial achievements.
Tiago Pinho, Mário Lobo
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

Lean management of crisis response and post-pandemic outcomes in US primary care practices

open access: yesBMC Health Services Research
Background Primary care forms the basis for valued outcomes in health systems, including population health, high quality care, and reduced health expenditures.
Dorothy Y. Hung   +7 more
doaj   +1 more source

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