Results 61 to 70 of about 325,268 (268)
Enablers and Constraints in Implementing Lean Manufacturing: evidence from Brazilian SMEs [PDF]
, 2016 Lean Manufacturing has revolutionized the global manufacturing environment at an unprecedented rate. In scholarly and managerial literature, many works have reported that Lean Manufacturing is a very efficient approach and a straightforward way towards ...
Ferreira Viagi, A. +3 more
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Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
The contribution of industry 4.0 to lean manufacturing
, 2023 The term Industry 4.0 (I.4.0) has often been cited and is directly linked to the future of manufacturing activities, and within this context, interfaces with other concepts such as Lean Manufacturing occur, and the latter can benefit from the benefits ...
Oian, Carlos Alberto
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COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Application of Lean Healthcare: a case study in a general hospital [PDF]
, 2016 This paper deals with the presence of Lean Production System in hospitals, known as Lean Healthcare. The aim is to identify the applicability of Lean practices in the management of a general hospital. The research method used was a qualitative case study,
Oliveira Rodrigues, Ana Cristina +1 more
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Value flow structure and analysis to support Lean initiatives in surgical centers [PDF]
, 2020 Lean in hospitals can provide expressive results and benefits for several stakeholders. In these settings, Lean introduction in surgical centers could support improvements, such as staff and patient’s satisfaction increase and reduction of non-value ...
Ulhoa, Túlio Fígaro +3 more
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Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Evaluating lean in healthcare [PDF]
The overarching aim of this thesis is to evaluate Lean implementation in the English NHS. Against a background of financial austerity measures and the ostensible widespread adoption of Lean in the UK public sector, and particularly by healthcare ...
Burgess, Nicola
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Interaction of Lean and Building Information Modeling in Construction [PDF]
, 2010 Lean construction and Building Information Modeling are quite different initiatives, but both are having profound impacts on the construction industry. A rigorous analysis of the myriad specific interactions between them indicates that a synergy exists ...
Koskela, L +11 more
core +1 more source