Results 41 to 50 of about 325,268 (268)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Moving on - beyond lean thinking
, 2004 Lean Thinking is currently often positioned as the underlying theory of lean production among practitioners and academics, although its originators, Womack and Jones, seem not to have presented it as a theory. This paper endeavors to analyze whether Lean
Koskela, LJ, Koskela, Lauri
core
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
Lean construction: Prospects for the German construction industry
, 2007 There is little, if any, information available about the range and dissemination of lean concepts among construction companies in Germany. Building on the methodologies and conceptual frameworks used in earlier work in the UK (Common et al., 2000) and ...
Walter, Lorenz, Johansen, Eric
core
Application of lean tools in health care: a literature review [PDF]
, 2016 The lean philosophy has been used in various sectors, while the services sector is one that has more bet on this philosophy, including health services. This work aims to contribute to the description of the current state of implementation of lean tools ...
Boschetto, Jessica Werner +2 more
core
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Implementing lean: UK culture and systems change
, 2004 For the IGLC 12 Conference the authors reported the results of implementing Last PlannerTM methods with a large UK contracting company. The projects studied demonstrated some success but also some cultural, organizational and systemic barriers to its ...
Greenwood, David +2 more
core
An adaptive method for assessing the implementation degree of lean production [PDF]
, 2020 The implementation of lean production is a continuous improvement process that requires the assessment of its progress over time. On the other hand, adaptations to the implementation and assessment of lean production are usually necessary, since each ...
Vilar, Flora Magna do Monte +1 more
core
Biophysical approaches for studying viral entry
FEBS Letters, EarlyView.Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley +1 more source