Results 51 to 60 of about 325,268 (268)
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Evaluation of the influence of Lean management practices on productivity [PDF]
, 2019 The lean practices have a fundamental role in the continuous improvement and to leverage the performance of a company. From such point of view, the management style of a business is a key factor to its development against competitors.
Canonica, Gabriel +2 more
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Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Lean startups: o sistema de produção enxuta como estratégia competitiva [PDF]
, 2016 As lean startups adotam o lean thinking para a condução de seus processos empreendedores. A coordenação do gerenciamento orientada ao cliente por meio do customer development aprimora a margem de sucesso a ser obtido pelas organizações. O presente artigo
Straehl de Sousa, João Benício
core
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Lean logistics as support for strategic management practice [PDF]
, 2020 According to Hines, Holweg and Rich (2004), lean can be applied across several segments, including supply chain aspects, providing benefits to the organization.
Santos, Pedro Vieira Souza +1 more
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Application of lean office concepts for information flow improvement in a veterinary industry [PDF]
, 2021 The national veterinary industry has experienced a representative growth and a large maturation, leading to continuous improvement and expansion of its competitiveness, seeking the improvement of the management processes.
Franco, Karen Andrade +1 more
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Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Lean IT application in service desk in a wires and cable company [PDF]
, 2018 Lean thinking has influenced many organizations around the world, being widely diffused in the manufacturing context, with ramifications in other areas such as Logistics and Information Technology (IT), and this last area became known as Lean IT.
Ferreira, William de Paula +4 more
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Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source