Results 111 to 120 of about 1,091,104 (305)
What are Some of the Best Ways to Assess and Measure Operational Team Performance in a Lean Innovation Environment? [PDF]
, 2017 [Excerpt] Lean innovation is a concept that has been gaining attention in the recent years. It began as a concept for start-ups; entrepreneurs with creative ideas wanting to provide the most value to their stakeholders using the least resources, but has ...
Nazim, Javeria, Sims, Lauren
core +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
The Remote Site Doctrine in Alaska [PDF]
, 2004 In recent years, software development has been evolving around an Agile way of working to optimize software development processes. Simultaneously in other industries, the Leanconcept have been adopted and used to make manufacturing and production of ...
Dahlman, Maria, Olsson, Ulrika
core +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
The effects of Lean and people’s behaviours on Occupational Safety
Production Engineering ArchivesLean methodologies have been implemented in various sectors, helping to improve the overall efficiency and performance of organisations. The aim of this research is to investigate the relationship between Lean and occupational safety and its impact on ...
Sá José Carlos +8 more
doaj +1 more source
Organization, Technology and Management in Construction: An International Journal, 2019 Supply chain management (SCM), for the past two decades, has been identified by manufacturing industries as a new way of doing business. Construction, similar to manufacturing and other services industries, is experiencing emerging trends that are aimed ...
Boateng Ali
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Improving the preanalytical process: the focus on specimen quality [PDF]
Journal of Medical Biochemistry, 2008 Trends in clinical laboratory practice place more demands on the quality of patient specimens. Advances in analytical performance (i.e., increased automation, reduced sample volume, increased assay sensitivity), as well as efficiency and cost reduction ...
Green Sol
doaj
Becoming a Lean University: the case of the University of St Andrews [PDF]
, 2015 This article looks at how “lean” can be successfully introduced into a higher education setting by discussing what has become known as ‘The St Andrews Model’.
Robinson, Mark, Yorkstone, Steve
core