Results 91 to 100 of about 11,060,629 (282)
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Where Rhetoric and Lean Meet [PDF]
, 2015 This paper aims at an initial analysis and explanation of lean through the lens of the discipline of rhetoric. First, the ancient origin, central ideas, subsequent history and current interpretations of rhetoric are outlined.
Koskela, Lauri
core +1 more source
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
Risk Management in Lean Product Development [PDF]
, 2010 This whitepaper summarizes 15 years of research conducted at MIT's Lean Advancement Initiative on the topic of risk management in product design and development.
Rebentisch, Eric, Oehmen, Josef
core
Comparing production design activities and location-based planning tools
, 2017 What are the differences between production system design and work structuring? And between phase scheduling and work structuring? Which lean planning tool is better suited for each one of these design processes: line of balance, takt-time planning or ...
Kagioglou, Mike (R20008) +8 more
core +1 more source
Towards a holistic view of customer value creation in Lean: A design science approach
Cogent Business & Management, 2019 While “identifying customer value” is the first principle of Lean thinking, the concept of customer value has largely remained unchanged in the Lean discourse - quality, cost and delivery.
Erdoğan Gülyaz +3 more
doaj +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
How analysis and synthesis have been understood in design [PDF]
, 2006 In the disciplines related to the design of products and services, such as New Product Development and Design Science, there is a lack of a commonly accepted theoretical and methodical basis.
Kagioglou, Mike (R20008) +5 more
core
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source