Results 121 to 130 of about 221,276 (349)
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Discover Applied SciencesThe present study investigates the integration of Lean and Sustainable manufacturing (LSM) practices to improve the market competitiveness of Indian manufacturing organizations.
Sumit Gupta +4 more
doaj +1 more source
Lean and Virginia's wood industry - Part I: Awareness and implementation [PDF]
BioResources, 2012 During the most recent decades the U.S. wood products and furniture manufacturing industries have been greatly affected by economic cycles, rising production and transportation costs, changing buyer habits, and, arguably most powerfully, increasing ...
Christian F. Fricke, Urs Buehlmann
doaj
The Double-D cell for assembling hardware in upholstered furniture production [PDF]
, 2004 This is the first case study in a series of studies that relate specifically to the development and application of lean manufacturing techniques of furniture and wood component supplying industries.
Bullard, Steven H +3 more
core +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
The Hybrid Lean System to Improve Manufacturing Environment
MATEC Web of Conferences, 2017 Lean manufacturing is a systematic approch could increase manufacturing competitiveness by identifying and elminating waste through lean tools. However, these tools are often categorized into different groups, continues to be difficult for companies to ...
Ahmad Ahmad Nur Aizat +5 more
doaj +1 more source
An empirical analysis of lean six sigma implementation in SMEs – A migratory perspective [PDF]
, 2013 The purpose of this paper is to investigate the migratory nature of Lean Six Sigma (LSS) implementation in manufacturing based SMEs in the UK. The companies were surveyed at two points over a five year period. These periods were before and after the 2008
Byard, Paul +3 more
core
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source