Results 111 to 120 of about 214,336 (304)

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

Validasi Proses Produksi sebagai Bagian Implementasi Lean Manufacturing di Industri Farmasi [PDF]

open access: yes, 2017
Industri farmasi nasional sedang menghadapi persaingan yang meningkat, tekanan biaya dan keefektifan kinerja operasi manufakturnya. Lean manufacturing menawarkan metode, alat dan program untuk meningkatkan produktivitas.
Widhiswastiawan, T. A. (Thomas)
core  

Exploring the impact of Lean manufacturing on flexibility in SMEs [PDF]

open access: yes, 2017
Purpose: This paper describes the use of simulation and case-study research to assess flexibility gains induced by the adoption of three Lean Manufacturing practices.
Lucherini, Franco, Rapaccini, Mario
core   +5 more sources

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

open access: yesFEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold   +11 more
wiley   +1 more source

Improving supply chain management in construction: what can be learned from the aerospace industry? [PDF]

open access: yes, 2003
In order to provide for controllable delivery, reliable lead times and efficient customer response, lean manufacturing and platform assembly practices play an important role in supply chains in the aerospace industry.
Voordijk, H., Vrijhoef, R.
core   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

open access: yesFEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti   +3 more
wiley   +1 more source

Sustainable manufacturing: Exploring antecedents and influence of Total Productive Maintenance and lean manufacturing

open access: yesAdvances in Mechanical Engineering, 2019
This article explores the environment-related antecedents and the influence of Total Productive Maintenance and other lean manufacturing practices on environmental sustainability.
Ping-Kuo Chen   +3 more
doaj   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

open access: yesFEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida   +6 more
wiley   +1 more source

Unveiling the synergy of sustainable manufacturing practices and lean for sustainable manufacturing competitiveness

open access: yesDiscover Applied Sciences
The present study investigates the integration of Lean and Sustainable manufacturing (LSM) practices to improve the market competitiveness of Indian manufacturing organizations.
Sumit Gupta   +4 more
doaj   +1 more source

How Blockchains Improve Lean Manufacturing Tools in the Industry 4.0 Context

open access: yesEngineering Proceedings
Lean manufacturing (LM) is one of the strongest tools used by manufacturing companies to improve and optimize their processes, making them more performant and agile.
Rouidi Ibrahim   +2 more
doaj   +1 more source

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