Results 111 to 120 of about 30,769 (308)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Unveiling the synergy of sustainable manufacturing practices and lean for sustainable manufacturing competitiveness

Discover Applied Sciences
The present study investigates the integration of Lean and Sustainable manufacturing (LSM) practices to improve the market competitiveness of Indian manufacturing organizations.
Sumit Gupta, Deepika Joshi, Anbesh Jamwal, Neeraj Bhanot, Sandeep Jagtap   +4 more
doaj   +1 more source

Lean and Virginia's wood industry - Part I: Awareness and implementation [PDF]

BioResources, 2012
During the most recent decades the U.S. wood products and furniture manufacturing industries have been greatly affected by economic cycles, rising production and transportation costs, changing buyer habits, and, arguably most powerfully, increasing ...
Christian F. Fricke, Urs Buehlmann
doaj  

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Objetivos y decisiones estratégicas operacionales como apoyo al lean manufacturing [PDF]

, 2017
El objetivo de la presente investigación consistió en identificar los mecanismos de coordinación entre las herramientas de lean manufacturing y la estrategia de operaciones en siete compañías del sector textil ubicadas en el Valle de Aburrá, Colombia. Se
González Gaitán, Henry Helí, Fundación Universitaria Konrad Lorenz, Marulanda Grisales, Natalia   +2 more
core  

Application of lean manufacturing concepts and value stream mapping to a company that manufactures engineering to order road transportation products

, 2014
Paper presented at the Proceedings of the 24th International Conference on Flexible Automation & Intelligent Manufacturing, held May 20-23, 2014 in San Antonio, Texas, and organized by the Center for Advanced Manufacturing and Lean Systems ...
Ferreira, Joao C. E., João C. E. Ferreira, Fernanda A. Breitenbach, Breitenbach, Fernanda A.   +3 more
core   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Inclusive tool to assess lean manufacturing maturity and its relationship with the size or location of the company in Greater Montreal, Canada

Cogent Engineering
Manufacturing companies operate in aggressive environments and require high productivity for survival. This study examined the implementation status of lean manufacturing practices in a sample of Greater Montreal’s industries by assessing maturity levels
Didérot Déraillet Tadja, Fatma Lehyani, Samuel-Jean Bassetto, Alaeddine Zouari, Michel Tollenaere, Tony Wong   +5 more
doaj   +1 more source

The Hybrid Lean System to Improve Manufacturing Environment

MATEC Web of Conferences, 2017
Lean manufacturing is a systematic approch could increase manufacturing competitiveness by identifying and elminating waste through lean tools. However, these tools are often categorized into different groups, continues to be difficult for companies to ...
Ahmad Ahmad Nur Aizat, Lee Te Chuan, Ramlan Rohaizan, Ahmad Md. Fauzi, Husin Norafifah, Abdul Rahim Mustaqqim   +5 more
doaj   +1 more source

Lean and Automate Manufacturing and Logistics [PDF]

, 2013
This paper presents the Lean and Automate method on how to streamline and automate simultaneously the production and logistics processes in order to improve quality, reduce waste, and increase agility using Lean Six Sigma with the support of some advanced technologies. The approach is based on research which showed that for the best application of Lean
openaire   +2 more sources