Results 91 to 100 of about 1,391,913 (277)

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

Integrating Lean Manufacturing and Industry 4.0 for Enhanced Operational Performance [PDF]

openThis thesis examines the integration of Lean Manufacturing principles with Industry 4.0 technologies and their combined impact on organizational performance. The first chapter provides a brief overview of Lean manufacturing.
FILIPUZZI, GIULIA
core  

Understanding the relationship, trends, and integration challenges between lean manufacturing and industry 4.0. A literature review

International Journal of Production Management and Engineering
This  research  investigates  the  synergistic  relationship  between  Lean  Manufacturing  and  Industry  4.0,  crucial  paradigms  in  modern  industry,  through  a  literature  review  of  60  scientific  articles  published  from  January 2013  to ...
Tariq Benslimane, Rajaa Benabbou, Salma Mouatassim, Jamal Benhra   +3 more
doaj   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Beyond Lean: Simulation in Practice [PDF]

, 2011
Lean thinking, as well as associated processes and tools, have involved into a ubiquitous perspective for improving systems particularly in the manufacturing arena.
Standridge, Charles R., Ph.D.
core  

Supply Chain Optimization through the Implementation of Lean Manufacturing in the Manufacturing Industry

Spektrum Industri: Jurnal Ilmiah Pengetahuan dan Penerapan Teknik Industri
Manufacturing companies in emerging economies are increasingly challenged to improve supply chain performance amid rising competition, cost pressures, and demand uncertainty.
Semuel Pajala, Rusdiaman Rauf, Eric Alan Jones   +2 more
doaj   +1 more source

Value Stream Mapping to Improve Workplace to support Lean Environment

MATEC Web of Conferences, 2017
In recent years, lean manufacturing is being followed by various sectors in order to keep their competitiveness in the global markets. Lean manufacturing plays a vital role in improving the efficiency of operation by eliminating or reducing wastes ...
Ahmad Ahmad Nur Aizat, Lee Te Chuan, Ramlan Rohaizan, Ahmad Md. Fauzi, Husin Norafifah, Abdul Rahim Mustaqqim   +5 more
doaj   +1 more source

Development of Multivariate Framework for Lean and Green Process

Chemical Engineering Transactions, 2018
The supply and demand on manufacturing industry has always been contributing significantly towards global economic growth. With the criticality of global warming and climate change, the manufacturing industry has suffered from being accused as the main ...
Wei Dong Leong, Hon Loong Lam, Chee Pin Tan, S G Ponnambalam   +3 more
doaj   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source