Results 71 to 80 of about 30,769 (308)

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Lean manufacturing maturity level: a case-study applied in the Brazilian auto-parts industry [PDF]

, 2022
Lean Manufacturing known as Toyota Production System is a systematic method of waste reduction within a manufacturing system without sacrificing its productivity, assisting on the identification and steady elimination of waste.
Kakazu, Keila Yuri, Ibusuki, Ugo
core  

Lean Implementation in Singapore: A Survey in SMEs of the Precision and Electronics Manufacturing Industry

Information
This study examines how lean manufacturing practices are adopted in Singapore’s SME precision and electronics manufacturing industry. Its main goal is to assess the extent of lean manufacturing method adoption and the challenges involved.
Keat Chin Yeoh, Pedro Alexandre De Albuquerque Marques, Arlindo Silva   +2 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Lean manufacturing measurement: the relationship between lean activities and lean metrics

Estudios Gerenciales, 2007
Lean Manufacturing fue desarrollado por Toyota Motor Company para abordar sus necesidades específicas en un mercado restringido en tiempos de problemas económicos. Estos conceptos han sido estudiados y han demostrado ser transferibles y aplicables a una amplia variedad de industrias. Este trabajo tiene como objetivo integrar un conjunto de métricas que
Diego Fernando Manotas-Duque, Leonardo Rivera   +1 more
openaire   +4 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Lean management in a non-manufacturing organization

Ekonomski Vjesnik, 2013
This paper examines the possibilities of a lean approach to non-manufacturing functions, i.e. a market-oriented organization. This refers to purchasing, shipment, storage, sale and delivery of goods; marketing, etc.
Mladen Žvorc
doaj  

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Quality based strategy: modelling for lean manufacturing [PDF]

, 1994
The research develops and applies an integrated methodology for creating a Lean Manufacturing Environment in a traditional industry: the Portuguese Textile and Clothing Industry. This is achieved by developing a modelling tool using quality as a basis
Cruz Machado, Virgilio A.
core  

Digital Leadership and Lean Manufacturing: An Analysis Using an Importance–Performance Map

Forum Scientiae Oeconomia
The success of lean manufacturing practices in Industry 4.0 is highly dependent on people and technology; therefore, an appropriate leadership style is essential when pursuing the implementation of lean manufacturing.
Maria Marisela Vargas-Salgado, Aurora Irma Maynez-Guaderrama, Erwin Adan Martinez-Gomez, Andres Hernandez-Gomez, Vianey Torres-Arguelles   +4 more
doaj   +1 more source