Results 61 to 70 of about 214,336 (304)
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
AN EXPLORATORY STUDY ON EMPLOYEE’S PERCEPTION TOWARDS LEAN MANUFACTURING SYSTEMS [PDF]
Management & Marketing, 2012 Lean deals with generating more value for customers by eliminating factors that are merely considered waste. Lean Manufacturing is a systematic approach to identifying and eliminating waste through continuous improvement.
Rajesh Kumar MEHTA +2 more
doaj
Analysing the adoption of Lean production in remanufacturing industry
Journal of Industrial Engineering and Management, 2018 Purpose: This paper aims to analyse the challenges of lean manufacturing implementation in the remanufacturing industry. The research was undertaken in three types of remanufacturing company, torque converter, gearbox, and jet engine remanufacturers ...
Anjar Priyono, Fazli Idris
doaj +1 more source
Becoming a Lean University: the case of the University of St Andrews [PDF]
, 2015 This article looks at how “lean” can be successfully introduced into a higher education setting by discussing what has become known as ‘The St Andrews Model’.
Robinson, Mark, Yorkstone, Steve
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Performance optimization of a leagility inspired supply chain model: a CFGTSA algorithm based approach [PDF]
, 2009 Lean and agile principles have attracted considerable interest in the past few decades. Industrial sectors throughout the world are upgrading to these principles to enhance their performance, since they have been proven to be efficient in handling supply
Agarwal A +18 more
core +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
From Micro to Macro: A Comprehensive Study of Lean Manufacturing Tools in Tanzanian Industries
Engineering ReportsThe study aimed to establish the adoption status of tools and practices, drivers, and barriers for Lean Manufacturing (LM) for the Tanzanian context based on the industry size. The study adopted a survey research design.
Francis D. Sinkamba +2 more
doaj +1 more source
Business Sphere, Vol. 17, no.3 [PDF]
, 2005 Through networking, Iowa’s manufacturers share expertise in lean manufacturing, supply chain efficiency and rapid prototyping, strengthening the powerful environment for success.
core
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source