Results 41 to 50 of about 30,769 (308)
Implementation of lean manufacturing process to XYZ Company in Minneapolis area [PDF]
, 2004 Plan BToday, numerous companies have a major opportunity to reduce their costs and customer lead time and cycle time through the application of Lean Manufacturing processes.
Yamashita, Kazuhiro
core
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Development of an impact assessment framework for lean manufacturing within SMEs [PDF]
, 2007 The main aim of the research work presented in this thesis, is the development of a novel framework with the capability of assessing the impact of implementing lean manufacturing within small-to-medium sized manufacturing firms (SMEs).
Achanga, Pius Coxwell
core
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Lean manufacturing for SMEs: Enabling rapid response to demand changes [PDF]
, 2005 Small-to-medium-sized manufacturing enterprises (SMEs) make significant contributions to most national economies. In the UK for instance, SMEs account for up to 40% of gross domestic product (GDP) and 85% of newly created jobs.
Shehab, Essam +3 more
core
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
A lean framework for tooling design process in Chinese aerospace [PDF]
, 2012 Lean Manufacturing (LM) has been used in production processes to help manufacturing companies maintain competitive advantages for decades. However, with the increasingly fierce competition and pressure to sustain survival and long-term growth ...
Yang, Yafang
core
BioResources, 2009 Lean Manufacturing has helped several industries to achieve operational and manufacturing excellence by increasing productivity and enhancing quality, while reducing waste and costs.
Adrian Pirraglia +2 more
doaj
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source