Digital Leadership and Lean Manufacturing: An Analysis Using an Importance–Performance Map
The success of lean manufacturing practices in Industry 4.0 is highly dependent on people and technology; therefore, an appropriate leadership style is essential when pursuing the implementation of lean manufacturing.
Maria Marisela Vargas-Salgado +4 more
doaj +1 more source
Integrated Impact of Circular Economy, Industry 4.0, and Lean Manufacturing on Sustainability Performance of Manufacturing Firms. [PDF]
Ghaithan AM +3 more
europepmc +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Effect of lean manufacturing tools on sustainability: the case of Mexican maquiladoras. [PDF]
García-Alcaraz JL +5 more
europepmc +1 more source
Lean Manufacturing: Selected Financial Performance Of Recognized Lean Manufacturers
Since the Japanese development of lean manufacturing practices after World War II, American companies have slowly begun to embrace the concepts and results offered by the lean manufacturing concept. Companies in America did not fully embrace the value of the processes until the mid to late 1990s and some firms are finding that financial results that ...
Mehmet C. Kocakulah, Jim Upson
openaire +2 more sources
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
The roles of communication process for an effective lean manufacturing implementation
Many companies are implementing lean manufacturing concept in order to remain competitive and sustainable, however, not many of them are successful in the process due to various reasons.
Perumal Puvanasvaran +3 more
doaj +1 more source
Mediating Role of Green Supply Chain Management Between Lean Manufacturing Practices and Sustainable Performance. [PDF]
Awan FH +6 more
europepmc +1 more source
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
Implementing Digitalised Lean Manufacturing Training in a UK Engine Manufacturing Centre During the SARS-CoV2 Pandemic of 2020. [PDF]
McKie MG, Jones R, Miles J, Jones IR.
europepmc +1 more source

