Results 81 to 90 of about 30,769 (308)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Superior contractor performance : a barrier to lean construction adoption in Australia

open access: yes, 2022
The Australian construction industry produces twice as much value per dollar while enduring four times the competition than manufacturing. Impressively, this sector outpaces six of nine major industries in the country. However, their quantitative success
Stevens, Matt (R19432)
core   +1 more source

The roles of communication process for an effective lean manufacturing implementation

open access: yesJournal of Industrial Engineering and Management, 2009
Many companies are implementing lean manufacturing concept in order to remain competitive and sustainable, however, not many of them are successful in the process due to various reasons.
Perumal Puvanasvaran   +3 more
doaj   +1 more source

Relationship between lean manufacturing tools and their sustainable economic benefits. [PDF]

open access: yesInt J Adv Manuf Technol, 2022
Díaz-Reza JR   +4 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Enablers and Constraints in Implementing Lean Manufacturing: evidence from Brazilian SMEs [PDF]

open access: yes, 2016
Lean Manufacturing has revolutionized the global manufacturing environment at an unprecedented rate. In scholarly and managerial literature, many works have reported that Lean Manufacturing is a very efficient approach and a straightforward way towards ...
Ferreira Viagi, A.   +3 more
core  

Effect of lean manufacturing tools on sustainability: the case of Mexican maquiladoras. [PDF]

open access: yesEnviron Sci Pollut Res Int, 2022
García-Alcaraz JL   +5 more
europepmc   +1 more source

Lean Manufacturing: Selected Financial Performance Of Recognized Lean Manufacturers

open access: yesInternational Business & Economics Research Journal (IBER), 2011
Since the Japanese development of lean manufacturing practices after World War II, American companies have slowly begun to embrace the concepts and results offered by the lean manufacturing concept. Companies in America did not fully embrace the value of the processes until the mid to late 1990s and some firms are finding that financial results that ...
Mehmet C. Kocakulah, Jim Upson
openaire   +2 more sources

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

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