Results 81 to 90 of about 1,391,913 (277)

Digital Leadership and Lean Manufacturing: An Analysis Using an Importance–Performance Map

open access: yesForum Scientiae Oeconomia
The success of lean manufacturing practices in Industry 4.0 is highly dependent on people and technology; therefore, an appropriate leadership style is essential when pursuing the implementation of lean manufacturing.
Maria Marisela Vargas-Salgado   +4 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

open access: yesMolecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim   +11 more
wiley   +1 more source

Effect of lean manufacturing tools on sustainability: the case of Mexican maquiladoras. [PDF]

open access: yesEnviron Sci Pollut Res Int, 2022
García-Alcaraz JL   +5 more
europepmc   +1 more source

Lean Manufacturing: Selected Financial Performance Of Recognized Lean Manufacturers

open access: yesInternational Business & Economics Research Journal (IBER), 2011
Since the Japanese development of lean manufacturing practices after World War II, American companies have slowly begun to embrace the concepts and results offered by the lean manufacturing concept. Companies in America did not fully embrace the value of the processes until the mid to late 1990s and some firms are finding that financial results that ...
Mehmet C. Kocakulah, Jim Upson
openaire   +2 more sources

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

open access: yesMolecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba   +5 more
wiley   +1 more source

The roles of communication process for an effective lean manufacturing implementation

open access: yesJournal of Industrial Engineering and Management, 2009
Many companies are implementing lean manufacturing concept in order to remain competitive and sustainable, however, not many of them are successful in the process due to various reasons.
Perumal Puvanasvaran   +3 more
doaj   +1 more source

Mediating Role of Green Supply Chain Management Between Lean Manufacturing Practices and Sustainable Performance. [PDF]

open access: yesFront Psychol, 2021
Awan FH   +6 more
europepmc   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

open access: yesMolecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir   +9 more
wiley   +1 more source

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