Results 81 to 90 of about 3,455,968 (292)

Carotid Intima‐Media Thickness but Not Carotid Artery Plaque in Healthy Individuals Is Linked to Lean Body Mass

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Lean body mass has been identified as a key determinant of left ventricular mass and wall thickness. However, the importance of lean body mass or other body‐size measures as normative determinants of carotid intima‐media thickness (cIMT), a ...
Matthew Arnold, Andrew Linden, Robert Clarke, Yu Guo, Huaidong Du, Zheng Bian, Eric Wan, Meng Yang, Liang Wang, Yuexin Chen, Jianwei Chen, Huajun Long, Qijun Gu, Rory Collins, Liming Li, Zhengming Chen, Sarah Parish   +16 more
doaj   +1 more source

Changes in lean mass and fat mass in children with osteogenesis imperfecta

Endocrine Abstracts
Deficits in skeletal muscle and function, with resultant abnormal body composition, is a recognised feature of Osteogenesis Imperfecta (OI). Less is known about longitudinal change in body composition in OI. Our objective was to perform a retrospective analysis of longitudinal change in body composition (lean mass and fat mass) in children with OI.Data
Holly Wright, Sze Choong Wong, Misha Gilani, Helen McDevitt, Sheila Shepherd, Avril Mason   +5 more
openaire   +2 more sources

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Enabling lean design management: An LOD based framework [PDF]

, 2016
Question: How can we use the Level of Development (LOD) concept to better develop BIM models under a Transformation, Flow and Value (TFV) perspective?
Hamzeh, Farook R., Abou-Ibrahim, Hisham A.   +1 more
core  

Lean tools applied in urban public transportation [PDF]

, 2019
The present paper has the objective of proposing an application of the tools of the lean philosophy in urban public transport companies of the north of Santa Catarina.
Garcia, Janaina Renata, Antonowicz, Mariane Alexandra, Zagheni, Elisete Santos da Silva   +2 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Resistance training-induced appendicular lean tissue mass changes are largely unrelated to pre-training bone characteristics in a larger cohort of untrained adults

Frontiers in Physiology
IntroductionWe sought to determine if pre-intervention bone characteristics measured by dual-energy x-ray absorptiometry (DXA) were associated with changes in bone-free lean tissue mass following a period of resistance training in a large cohort of ...
Dakota R. Tiede, Daniel L. Plotkin, Mason C. McIntosh, J. Max Michel, Kevin W. Huggins, Darren T. Beck, Darren T. Beck, Michael D. Goodlett, Joshua C. Carr, Brad J. Schoenfeld, Christopher B. Mobley, Kaelin C. Young, Paul A. Swinton, Andrew D. Frugé, Andrew D. Frugé, Michael D. Roberts, Michael D. Roberts   +16 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Lean & Green and the life cycle stages of constructions: literature mapping and trend analysis [PDF]

, 2021
The synergy between lean production and sustainability can bring competitive advantages to civil construction companies, with increased productivity and reduced negative environmental impacts.
Silva, Diogo Aparecido Lopes, Moris, Virgínia Aparecida da Silva, Silva, Daiane Vitória da, Rezende, Marília de Oliveira   +3 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source