Results 51 to 60 of about 334,567 (311)
Discrete costing versus collaborative costing [PDF]
, 2017 The UK construction industry has witnessed a recent shift towards integrated and collaborative approaches. Such collaborative efforts include the use of integrated systems like BIM, lean and innovative procurement options which are now reshaping project ...
Manu, E, Namadi, SA, Pasquire, C
core +2 more sources
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
A new lean change methodology for small & medium sized enterprises [PDF]
, 2010 SMEs find it difficult to implement productivity improvement tools, particularly those associated with Lean Manufacturing. Larger companies have more success due to greater access to resources. To provide the SMEs with a way to implement Lean sustainably,
April, Joris +2 more
core +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Applying Level of Detail in a BIM-Based Project: An Overall Process for Lean Design Management
Buildings, 2019 Few construction companies apply the available lean tools and processes in an integrated manner when managing design. Additionally, lean design management tools and processes each have their own strengths and optimal phases in which they should be ...
Petteri Uusitalo +4 more
doaj +1 more source
Reforming project management: the role of lean construction [PDF]
, 2000 Project management as taught by professional societies and applied in current practice must be reformed because it is inadequate today and its performance will continue to decline as projects become more uncertain, complex and pressed for speed.
Howell, GA, Koskela, LJ
core
Building an Entrepreneurship Data Warehouse
, 2017 The main principle of the Lean Startup movement is that static business planning should be replaced by a dynamic development, where products, services, business model elements, business objectives and activities are frequently changed based on constant ...
Abrahamsson, Pekka +3 more
core +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Lean Six Sigma: Application of the Methodology in Data Processing for Cancer Registry
Medical Sciences Forum, 2023 Since 2020, the Catania-Messina-Enna Cancer Registry (CR) has operated a transformational and incremental program while also applying a Lean Six Sigma methodology (LSS) to optimize the processes and reduce waste.
Paolo Fidelbo +6 more
doaj +1 more source
LEAN PROCUREMENT: THE USE OF LEAN CONSTRUCTION TECHNIQUES IN PROJECT VALUE ENHANCEMENT [PDF]
, 2012 Lean construction is characterised by a set of clear objectives in project delivery involving the concurrent design of products and processes, and the application of production control throughout the project life cycle to maximise value for money to ...
Goulding, Jack Steven +2 more
core