Results 61 to 70 of about 334,567 (311)

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Challenges and success factors for implementation of lean manufacturing in European SMES [PDF]

open access: yes, 2011
Small and medium-sized enterprises are crucial to value creation in the European economy. The SMEs need continuous improvement initiatives to stay competitive.
Bakås, Ottar   +2 more
core   +1 more source

Reducing the delivery lead time in a food distribution SME through the implementation of six sigma methodology [PDF]

open access: yes, 2009
Purpose – Six sigma is a systematic data driven approach to reduce the defect and improve the quality in any type of business. The purpose of this paper is to present the findings from the application of six sigma in a food service “small to medium sized
Nabhani, Farhad, Shokri, Alireza
core   +2 more sources

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

open access: yesMolecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor   +2 more
wiley   +1 more source

Lean Project Management using Unmanned Aerial Vehicles

open access: yesTamap Journal of Engineering, 2019
Development of a lean and automated progress tracking system is one of the most challenging subjects in the construction industry. Since the current methods depend on individual and manual inspections of the site, they may have various problems. For instance, results include a natural bias since field personnel makes interpretations depending on their ...
Ersöz, Ahmet Bahaddin   +2 more
openaire   +2 more sources

Creating Social Value within the Delivery of Construction Projects [PDF]

open access: yes, 2018
The purpose of this paper is to present the current knowledge surrounding social value and show how lean approach supports social value realisation in the delivery of construction projects. A critical literature review was adopted, to gather the current
Daniel, Emmanuel, Pasquire, Christine
core  

Molecular cancer prevention: Intercepting disease

open access: yesMolecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco   +2 more
wiley   +1 more source

Using post-occupancy evaluation of housing projects to generate value for municipal governments

open access: yesAlexandria Engineering Journal, 2018
This article presents a value-generation framework for municipalities through the adaptation of the Lean Project Delivery System (LPDS) to the municipal management process.
Xavier Brioso   +4 more
doaj   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

open access: yesFEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies   +3 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

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