Results 41 to 50 of about 98,677 (296)

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

A framework for the integration of green and lean six sigma for superior sustainability performance [PDF]

, 2016
Evidence suggests that Lean, Six Sigma and Green approaches make a positive contribution to the economic, social and environmental (i.e. sustainability) performance of organizations.
Ahmed Mokhlis, Alves J. R. X., Anass Cherrafi, Bae J. W., BEF, Bergmiller G. G., Carvalho H., EFQM, EFQM, EPA, EPA, EPA, EPA, Fliedner G., Franchetti M., Herrmann C., Jose Arturo Garza-Reyes, Kannan Govindan, Khalid Benhida, Klotz L., Kováčová Ľ., Langenwalter G., Longoni A., Malcolm Baldrige National Quality Award, Marudhamuthu R., Maskell B. H., MBNQA, McCarty T., Miller G., Moreira F., Pampanelli A. B., Park C., Pojasek R. B., Pojasek R. B., Pyzdek T., Said Elfezazi, SP, SP, Torielli R., Washington State Department of Ecology, Washington State Department of Ecology, Washington State Department of Ecology, Washington State Department of Ecology, Wilson A.   +43 more
core   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Pendekatan Servqual-lean Six Sigma Menggunakan Diagram Kontrol T2 Hotelling Untuk Meningkatkan Kualitas Pelayanan Pendidikan (Studi Kasus Di Jurusan Statistika Universitas Diponegoro) [PDF]

, 2015
Measurement the service of quality has an important role in improving and evaluating the performance of a service process. Measuring the service of quality is not as easy as measuring the goods quality, because the assessment service is subjective ...
Darwati, L. (Lulus), Mustafid, M. (Mustafid), Suparti, S. (Suparti)   +2 more
core   +3 more sources

Ranking the solutions of Sustainable Lean Six Sigma implementation in Indian manufacturing organization to overcome its barriers

International Journal of Sustainable Engineering, 2021
In today’s globally competitive market, manufacturing organisations must find innovative ways to delight stakeholders while achieving profitable growth.
Pranay Sureshbhai Parmar, Tushar N. Desai   +1 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Comparative Analysis of Lean and Six Sigma in Building Construction: Benefits, Obstacles and Opportunities [PDF]

, 2018
Lean and Six Sigma have been recognized as innovative strategies that can be used to transform a firm’s management practices to a newer level. However, there is little guidance, or evidence indicating whether Lean or Six Sigma enhance the construction ...
Fernandez-Solis, Jose L., Gadhok, Nipun
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

The Utilization of Lean Six Sigma Methodologies in Enhancing Surgical Pathways and Surgical Rehabilitation

Applied Sciences, 2023
The authors offer their perspective on the application of Lean Six Sigma methodology to surgical pathways, from referral to post-operative rehabilitation, and how it has resulted in sustainable improvements in patient outcomes, and patient and staff ...
Seán Paul Teeling, Michelle McGuirk, Martin McNamara, Marie McGroarty, Aileen Igoe   +4 more
doaj   +1 more source

Lean Six Sigma and marketing: a missed opportunity [PDF]

, 2014
Purpose – The purpose of this paper is to assess the current use being made of the sustainability message within business improvement activity and project justification within individual businesses.
Chaplin, Lara, O'Rourke, Simon T.J.
core   +1 more source