Results 51 to 60 of about 23,196 (348)
International Journal of Sustainable Engineering, 2021 In today’s globally competitive market, manufacturing organisations must find innovative ways to delight stakeholders while achieving profitable growth.
Pranay Sureshbhai Parmar +1 more
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Jurnal Jaminan Kesehatan Nasional, 2021 Pandemi covid-19 selama tahun 2020 membuat capaian peserta khusus segmen Pekerja Penerima Upah (PPU) mengalami penurunan, khususnya di kantor cabang Jakarta Selatan.Penelitian ini bertujuan untuk mengetahui dampak penerapan metode Lean Six Sigma dalam ...
Teguh Wijaya +3 more
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KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Improving Construction Processes by Integrating Lean, Green, and Six-Sigma [PDF]
, 2013 The overall goal of this research was to develop and implement methods to improve the performance and the efficiency of construction processes prior to and during the construction phase in Design-Bid-Build (DBB) projects.
Banawi, Abdulaziz
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Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Applied Sciences, 2023 The authors offer their perspective on the application of Lean Six Sigma methodology to surgical pathways, from referral to post-operative rehabilitation, and how it has resulted in sustainable improvements in patient outcomes, and patient and staff ...
Seán Paul Teeling +4 more
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Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
ACHIEVING COMPETITIVE ADVANTAGE THROUGH THE LEAN SIX SIGMA MODEL [PDF]
Analele Universităţii Constantin Brâncuşi din Târgu Jiu : Seria EconomieIn light of the intricate and evolving market landscape induced by globalisation and the health crisis, companies must swiftly respond to the actions of their competitors.
ANDRISAN GABRIELA NICOLETA +1 more
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