Results 71 to 80 of about 23,196 (348)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Lean six sigma application to transportation logistics

Revista Produção Online, 2012
This work presents the application of Lean Six Sigma in a case study of a metallurgic industry. The Six Sigma and the Lean are two processes used by enterprises in Brazil and worldwide.
Simone Tavares Fernandes, Fernando Augusto Silva Marins   +1 more
doaj   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Design for Six Sigma and lean product development

, 2012
Purpose – Six Sigma and lean production are established concepts in industry and academia. Both have given rise to associated concepts that have been applied in product development: Design for Six Sigma (DFSS) and Lean Product Development (LPD ...
Fouquet, J B, Gremyr, Ida, Gremyr, Ida,
core   +1 more source

Lean and Six Sigma Methodologies in NHS Scotland: An Empirical Study and Directions for Future Research

Kvalita Inovácia Prosperita, 2012
In recent years, the healthcare industry is constantly concerned to provide better quality of patient care with less waste of resources through application of continuous improvement (CI) initiatives such as Lean and Six Sigma.
Jiju Antony, Maneesh Kumar
doaj   +3 more sources

Integration of six sigma with lean production: an analysis through multiple cases

Revista Produção Online, 2013
The intense competition between markets has taken companies, regardless of their size, to implement one or more quality improvement programs. One of the main purposes of these programs is the enhancement of company effectiveness and efficiency.
Thiago Henrique Pinheiro, Alisson Christian Scheller, Paulo A Cauchick Miguel   +2 more
doaj   +1 more source

(A MELHORIA CONTÍNUA EM OPERAÇÕES DE TI) Desenvolvimento de um Modelo de Indicadores para Avaliação da Melhoria Contínua de Processos na Tecnologia da Informação Baseado no Lean Six Sigma [PDF]

, 2021
William Johnny Honorato, Marcelo Tsuguio Okano, Henry de Castro Lobo dos Santos, Alex Maia Viana   +3 more
openalex   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

A frontier in organizational and business process innovation in service management through lean six sigma Kaizen project implementation [PDF]

, 2017
Daniel D. Dasig, R Abdullah, M Selamat, S Sahibudin, R Alias, M Adams, P Componation, H Czarnecki, B Schroer, J Antony, J Antony, R Banuelas, J Antony, N Krishan, D Cullen, M Kumar, Z Atallah, A Ramudhin, S Athuraliya, S Low, V Li, Q Yin, M Ayuningrat, Noermijati, D Hadiwidjojo, K Barber, K Schultz, A Scott, E Pollock, J Kotecha, D Martin, C Bartolini, M Salle, D Trastour, M Bornemann-Shepherd, J Le-Lazar, M Makic, D Devine, K Mcdevitt, M Paul, M Brenner, P Brewer, N Bagranoff, R Gupta, K Prasad, L Luan, D Rosu, C Ward, M Harry, C Havens, Q He, J Yan, R Kowalczyk, H Jin, Y Yang, S Jain, C Mclean, M Jakobsson, N Rosenberg, F Kaminsky, J Benneyan, R Davis, R Burke, D Kellogg, W Nie, M Kuo, Y Chen, Y Kwak, F Anbari, S Lee, S Hong, K Linderman, R Schroeder, S Zaheer, A Choo, T Little, R Liu, D Mumford, E Page, A Parchami, M Mashinchi, H Maleki, W Pearn, A Psychogios, C Priporas, M Rossi, M Taisch, S Terzi, L Ramanan, M Kumar, K Ramanakumar, P Saraiva, G Stephanopoulos, W Schippers, A Shtub, R Karni, M Sokovic, D Pavletic, S Fakin, J Ward   +99 more
openalex   +3 more sources

Circular Economy in Manufacturing: Optimization using Lean Six Sigma [PDF]

E3S Web of Conferences
This research examines the amalgamation of Circular Economy concepts with Lean Six Sigma approaches to enhance manufacturing operations, emphasizing waste minimization, resource efficiency, and economic performance.
Orlov Alexandr K., Hussein Ramy Riad, Subbarayudu Yerragudipadu, Kapoor Tarun, Kumar Pramod, Kansal Lavish, Bhardwaj Nishant, Kumar Yogesh, Lakshmi K. Prasanna   +8 more
doaj   +1 more source