Results 41 to 50 of about 3,102,665 (275)

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Ranking the solutions of Sustainable Lean Six Sigma implementation in Indian manufacturing organization to overcome its barriers

International Journal of Sustainable Engineering, 2021
In today’s globally competitive market, manufacturing organisations must find innovative ways to delight stakeholders while achieving profitable growth.
Pranay Sureshbhai Parmar, Tushar N. Desai   +1 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Multiple case-study analysis of quality management practices within UK Six Sigma and non-Six Sigma manufacturing small- and medium-sized enterprises [PDF]

, 2009
This paper examines multiple case-study analysis of quality management practices within UK Six Sigma and non-Six Sigma manufacturing small- and medium-sized ...
Antony, J, Kumar, M
core   +4 more sources

Penerapan Metode Lean Six Sigma Dalam Upaya Rekrutmen Peserta PPU Badan Usaha: Study Kasus Proses Telemarketing Kantor Cabang Jakarta Selatan

Jurnal Jaminan Kesehatan Nasional, 2021
Pandemi covid-19 selama tahun 2020 membuat capaian peserta khusus segmen Pekerja Penerima Upah (PPU) mengalami penurunan, khususnya di kantor cabang Jakarta Selatan.Penelitian ini bertujuan untuk mengetahui dampak penerapan metode Lean Six Sigma dalam ...
Teguh Wijaya, Fanny Wiramijaya, Annisa Rahmania, Silvia Oktaviani   +3 more
doaj   +1 more source

Lean Six Sigma in Jordanian Organizations

International Journal of Economics and Business Administration, 2020
Purpose: The manufacturing sector with Lean Six Sigma is constantly improving (CI). CI is helping the organization to achieve and develop its efficiency and operational excellence. Synergizing all methods thus, helps to achieve better efficiency than using one method alone. This results in better quality. Thus, many companies have taken LSS for CI. Yet,
Mohummed Alomari, Khalid, Moh'd Mansour, Ahmad, Ali Almohtaseb, Ahmad, Salah, Ali A., Ismail Alshaketheep, Khaled, Abdullah abu Jray, Ahmad   +5 more
openaire   +3 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Integration of Industry 4.0 and Lean Six Sigma: Critical Success Factors for Overcoming Socioeconomic Challenges in the Telecommunication Sector [PDF]

SocioEconomic Challenges
The telecommunications industry faces significant socioeconomic challenges that impede competitiveness and operational excellence. Industry 4.0 and Lean Six Sigma offer solutions to these challenges through process automation, data-driven decision-making,
Ahmed Said El Shenawy, Nevien F. Khourshed, Mohamed A. Ragheb, Mahmoud H. Beshr   +3 more
doaj   +1 more source