Results 71 to 80 of about 134,821 (385)
Analyzing the Factors Enabling Green Lean Six Sigma Implementation in the Industry 4.0 Era
Sustainability, 2022 Green Lean Six Sigma has emerged in the Industry 4.0 era as a business strategy contributing to the circular economy by adopting the 3R concept, i.e., reduce, reuse, and recycle. Despite its broadly acknowledged capabilities in the manufacturing industry,
L. Letchumanan +6 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Comparative Analysis of Lean and Six Sigma in Building Construction: Benefits, Obstacles and Opportunities [PDF]
, 2018 Lean and Six Sigma have been recognized as innovative strategies that can be used to transform a firm’s management practices to a newer level. However, there is little guidance, or evidence indicating whether Lean or Six Sigma enhance the construction ...
Fernandez-Solis, Jose L., Gadhok, Nipun
core
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Combining six sigma with lean production to increase the performance level of a manufacturing system [PDF]
, 2015 2The application of innovative methodologies and problem solving methods to organize and manage manufacturing processes is essential to increase business performance of a company and satisfy customer demand. Specifically, combining Six Sigma quality with
core +1 more source
Lean Six Sigma in Healthcare: A Systematic Literature Review on Motivations and Benefits
Processes, 2022 While Lean Six Sigma (LSS) has been applied extensively in healthcare organisations, there has been limited research on the trends of LSS application in healthcare in recent years.
Olivia McDermott +6 more
semanticscholar +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Processes, 2022 Lean Six Sigma (LSS) has been applied in many healthcare organisations, but there has been limited research on the evolution of LSS application in healthcare.
Olivia McDermott +6 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source