Results 91 to 100 of about 879,996 (370)

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Challenges of Applying Agile Principles and Values to IT Project Management

Journal of Entrepreneurship, Management and Innovation, 2018
The theoretical part of this paper focuses on a macro-analysis of the Agile system philosophy, one of the most popular project management frameworks from the software industry. The second part of the paper consists of a case study analyzing the practices
Carmen Novac, Raluca Ciochina
doaj   +1 more source

Lean Startup –menetelmän käyttö laskeutusmissivun ja WebinarJam integraation toteuttamisessa – CASE: Opus Productions Oy [PDF]

, 2016
Opinnäytetyössä toteutettiin Opus Productions Oy:lle produktina ”laskeutumissivu” ja integraatio WebinarJam nimisen sovelluksen välillä. Laskeutumissivun kautta potentiaaliset Opus Productions Oy:n asiakkaat voivat rekisteröityä heidän järjestämilleen ...
Raunio, Konsta
core  

Lean and green – a systematic review of the state of the art literature [PDF]

, 2015
The move towards greener operations and products has forced companies to seek alternatives to balance efficiency gains and environmental friendliness in their operations and products.
Abdul Wahab, Aguado, Azevedo, Banawi, Bandehnezhad, Barnett-Page, Belekoukias, Besseris, Briner, Bryman, Cabral, Cabral, Cabral, Carvalho, Carvalho, Carvalho, Ceulemans, Chauhan, Chiarini, Cluzel, Darnall, Davids, Denyer, Dhingra, Dhingra, Diaz-Elsayed, Digalwar, Duarte, Duarte, Duarte, Duarte, Duarte, Dües, Esmemr, Espadinha-Cruz, Fink, Folinas, Forrester, Freyne, Galeazzo, Garza-Reyes, Garza-Reyes, Garza-Reyes, Gottberg, Govindan, Gunasekaran, Gupta, Hajmohammad, Hajmohammad, Herrmann, Herron, Hines, Hosseini, Jabbour, Johansson, Jose Arturo Garza-Reyes, Kainuma, King, Kitazawa, Kitchenham, Kleindorfer, Kurdve, Kurdve, Lambert, Larson, Lean and Green, Martinez-Jurado, Marx, Mashaei, Mason, Maxwell, Mollenkopf, Moreira, Nunes, Pampanelli, Parveen, Paumgartten, Puvanasvaran, QSR International, Ranky, Rothenberg, Rousseau, Salleh, Sarkis, Sarkis, Sarkis, Saunders, Sawhney, Sertyesilisik, Seuring, Simpson, Slack, Smith, Sobral, Thomas, Thorpe, Tice, Tranfield, Vais, Vargo, Verrier, Wadhwa, Webster, Wiengarten, Wong, Yang, Zhu   +106 more
core   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Exenatide Improves Bone Quality in a Murine Model of Genetically Inherited Type 2 Diabetes Mellitus [PDF]

, 2017
Type 2 diabetes mellitus (T2DM) is associated with skeletal complications, including an increased risk of fractures. Reduced blood supply and bone strength may contribute to this skeletal fragility.
Andreozzi, Anetzberger, Anichini, Aoyama, Baggio, Balint, Ban, Beckman, Bouxsein, Brunton, Chen, Coleman, Dempster, Ealey, Eckel, Feng, Flatt, Friedman, Griffith, Griffith, Hamilton, Hu, Karim, Kim, Lee, Lu, Ma, Mabilleau, Mabilleau, Mansur, Marenzana, Mieczkowska, Napoli, Nuche-Berenguer, Nuche-Berenguer, Nuche-Berenguer, Nystrom, Nystrom, Odgaard, Okerson, Orland, Orriss, Paschalis, Pereira, Pereira, Prisby, Richard, Roche, Roszer, Schalkwijk, Scheller, Selley, Shymkiw, Smits, Stabley, Sun, Tartaglia, Upadhyay, van Bloemendaal, Vijan, Williams, Wu, Yamamoto, Yamamoto, Yamamoto   +64 more
core   +5 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Lean Software Development [PDF]

, 2010
Steven C. Bell, Michael A. Orzen
  +4 more sources

Perancangan dan Implementasi Aplikasi Internet Radio Menggunakan Multimedia Database Melalui Penerapan Ontology dan Metadata

ComTech, 2012
The study aims to analyze, design and implement the internet radio application used in managing the audio data on Heartline FM radio station. In this application, the audio data which has been managed can be used in a radio broadcast scheduling.
M. Rudy Erwansyah, Ong Budi Setiawan, Bahtiar S. Abbas   +2 more
doaj   +1 more source

Dectin-1 Activation Exacerbates Obesity and Insulin Resistance in the Absence of MyD88 [PDF]

, 2017
This work was supported by Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP, grant numbers 11/15682-4, 12/02270-2, 15/18121-4), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, Regenera INCT Process Grant 465656/2014-5 ...
Aguiar, Cristhiane Favero, Albuquerque, José Antonio T., Almeida, Rafael Ribeiro, Amano, Mariane Tami, Andrade-Oliveira, Vinicius, Belchior, Thiago, Braga, Tarcio Teodoro, Brown, Gordon D, Castoldi, Angela, Câmara, Niels Olsen Saraiva, da Silva, Marina Burgos, Festuccia, Willian T., Gaiarsa, Jonas W., Hiyane, Meire Ioshie, Hoffmann, Christian, Ignácio, Aline, Latância, Marcela Teatin, Lee, Jennifer, Lima, Joanna Darck Carola C., Loures, Flávio V, Macêdo, Marina Barguil, Martínez, Luis A. Luévano, Miyagi, Marcelli Terumi, Moraes-Vieira, Pedro Manoel, Mori, Marcelo A., Seelaender, Marília   +25 more
core   +5 more sources