Results 51 to 60 of about 8,960 (250)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Accuracy of Video-Based Hand Tracking for People With Upper-Body Disabilities

IEEE Transactions on Neural Systems and Rehabilitation Engineering
Utilization of hand-tracking cameras, such as Leap, for hand rehabilitation and functional assessments is an innovative approach to providing affordable alternatives for people with disabilities.
Alexandra A. Portnova-Fahreeva, Momona Yamagami, Adria Robert-Gonzalez, Jennifer Mankoff, Heather Feldner, Katherine M. Steele   +5 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

The effects of leap motion-based virtual reality training on performance-based dexterity in children with Cerebral Palsy: a randomized controlled trial

Egyptian Pediatric Association Gazette
Background Performance-based dexterity is often limited in children with Cerebral Palsy (CP), affecting independence in daily activities. This study aimed to investigate the effectiveness of fine motor grasping exercises in a virtual reality (VR ...
Dilara Ergen, Ayşe Neriman Yılmaz
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

The Effects of Neuromuscular Electrical Stimulation and Leap Motion–Based Exercises on Hand Function Parameters in Children With Cerebral Palsy: Study Protocol for a Randomized Controlled Trial

JMIR Research Protocols
BackgroundCerebral palsy (CP) is a group of permanent but nonprogressive disorders that affect movement and posture, often accompanied by upper extremity impairments such as abnormal muscle tone, spasticity, weakness, and impaired motor control ...
Hande Özlü Erdoğan, Gülay Aras Bayram, Sema Targıt Akbaşak, Devrim Tarakcı   +3 more
doaj   +1 more source

Hand Tremor Based Biometric Recognition Using Leap Motion Device

IEEE Access, 2017
In this paper, the applicability of hand tremor-based biometric recognition via leap motion device is investigated. The hypothesis is that the hand tremor is unique for humans and can be utilized as a biometric identification.
Musa Atas
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source