Results 31 to 40 of about 11,700 (238)

العجز المتعلم وعلاقته بتقدير الذات وتحمل الغموض والطموح لدى عينة من المراهقين المکفوفين Learned helplessness and its relationship with self-esteem, Ambiguity Tolerance and ambition among a sample of Blind Adolescents [PDF]

مجلة التربیة الخاصة والتأهیل, 2016
تهدف الدراسة الحالية الى إيجاد العلاقة بين العجز المتعلم وتقدير الذات وتحمل الغموض والطموح لدى عينة من المراهقين المکفوفين. وقد تکونت عينة البحث من 30 طالب من المکفوفين بالمرحلة الثانوية. وتم تطبيق مقياس العجز المتعلم (الفرحاتى ،1997)، ومقياس تقدير الذات
شيماء أحمد السباعى
doaj   +1 more source

Learned helplessness and generalization

, 2013
In learned helplessness experiments, subjects first expe- rience a lack of control in one situation, and then show learning deficits when performing or learning another task in another situation. Generalization, thus, is at the core of the learned helplessness phenomenon.
Lieder, Falk, Goodman, Noah D., Huys, Quentin JM   +2 more
openaire   +3 more sources

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Learned Helplessness of Young People during the COVID-19 Distance Learning: A Research Report

Lubelski Rocznik Pedagogiczny, 2022
Introduction: Learned helplessness is a condition that arises as a result of a person’s belief that they are unable to control events. Having no sense of control over unpleasant experiences, a person learns that there is no relationship between the ...
Magdalena Kolber
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Prediction of learned helplessness based on academic resilience and test anxiety in students with academic failure [PDF]

Iranian Journal of Educational Research, 2023
The purpose of this research was to predict learned helplessness based on academic resilience and test anxiety among students with academic failure. The present research method was descriptive-correlation.
Mahdieh Abak
doaj