Results 91 to 100 of about 132,928 (250)
MiR‐513a promotes human erythroid differentiation by modulating c‐Jun
FEBS Open Bio, EarlyView.During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim +11 more
wiley +1 more source
Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system
FEBS Open Bio, EarlyView.An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková +3 more
wiley +1 more source
PLoS BiologyIntelligent behavior involves mentally arranging learned information in novel ways and is particularly well developed in humans. While nonhuman primates (NHP) will learn to arrange new items in serial order and re-arrange neighboring items within that ...
Xuan Wen +3 more
doaj +1 more source
Hybrid Fault Prognosis Using Health Index Fusion
AlgorithmsFault prognosis is a key enabler of predictive maintenance in modern industrial systems, where heterogeneous sensing, modeling, and data analytics coexist under varying operating conditions.
S. Mohsen Azizi, Faeze Ghofrani
doaj +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
FEBS Open Bio, EarlyView.Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley +1 more source
HIRE: A Hybrid Learned Index for Robust and Efficient Performance under Mixed Workloads
Indexes are critical for efficient data retrieval and updates in modern databases. Recent advances in machine learning have led to the development of learned indexes, which model the cumulative distribution function of data to predict search positions ...
Liang, Liang +3 more
core
WaZI: A Learned and Workload-aware Z-Index
Learned indexes fit machine learning (ML) models to the data and use them to make query operations more time and space- efficient. Recent works propose using learned spatial indexes to improve spatial query performance by optimizing the storage layout or
Wang, Yanhao +2 more
core +1 more source
SPLindex: A Spatial Polygon Learned Index [PDF]
Effective indexing is crucial for any AI and big data anal- ysis task involving huge datasets. Recently, machine-learned models for indexing have achieved much attention, and we apply such for spatial data, specifically huge collections of polygons.
Vahedi, Masoumeh, Christiansen, Henning
core +1 more source
Why human connection is the true metric of research success
FEBS Open Bio, EarlyView.Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source