Results 31 to 40 of about 407,217 (307)

Learning curve analysis of single-port thoracoscopic combined subsegmental resections

Frontiers in Oncology, 2023
BackgroundCombined subsegmental surgery (CSS) is considered to be a safe and effective resection modality for early-stage lung cancer. However, there is a lack of a clear definition of the technical difficulty classification of this surgical case, as ...
Yizhou Huang, Yizhou Huang, Yizhou Huang, Maohui Chen, Maohui Chen, Maohui Chen, Shuliang Zhang, Shuliang Zhang, Shuliang Zhang, Taidui Zeng, Taidui Zeng, Taidui Zeng, Guanglei Huang, Guanglei Huang, Guanglei Huang, Bin Zheng, Bin Zheng, Bin Zheng, Chun Chen, Chun Chen, Chun Chen   +20 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Learning curve for peroral endoscopic myotomy

Endoscopy International Open, 2016
Background and study aims: Although peroral endoscopic myotomy (POEM) is being performed more frequently, the learning curve for gastroenterologists performing the procedure has not been well studied.
Mohamad El Zein, Vivek Kumbhari, Saowanee Ngamruengphong, Kathryn A. Carson, Ellen Stein, Alan Tieu, Yamile Chaveze, Amr Ismail, Sameer Dhalla, John Clarke, Anthony Kalloo, Marcia Irene Canto, Mouen A. Khashab   +12 more
doaj   +1 more source

Assessment of teaching and learning burn treatment basics among medical students [PDF]

Revista Brasileira de Cirurgia Plástica, 2017
INTRODUCTION: Burns, an injury of high biopsychosocial importance, are a crucial issue in medical training, and newly graduated students face burn patients in a variety of professional settings.
Geiza Máximo, Aline Ferrari Martins, Luís Ricardo Martinhão Souto   +2 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

The Sex Inclusive Research Framework to address sex bias in preclinical research proposals

Nature Communications
An interactive Sex Inclusive Research Framework (SIRF) supports the evaluation of in vivo and ex vivo research proposals to address the risk of sex bias in preclinical research.
Natasha A. Karp, Manuel Berdoy, Kelly Gray, Lilian Hunt, Maggy Jennings, Angela Kerton, Matt Leach, Jordi L. Tremoleda, Jon Gledhill, Esther J. Pearl, Nathalie Percie du Sert, Benjamin Phillips, Penny S. Reynolds, Kathy Ryder, S. Clare Stanford, Sara Wells, Lucy Whitfield   +16 more
doaj   +1 more source

Learning Curve of Speech Recognition [PDF]

Journal of Digital Imaging, 2013
Speech recognition (SR) speeds patient care processes by reducing report turnaround times. However, concerns have emerged about prolonged training and an added secretarial burden for radiologists. We assessed how much proofing radiologists who have years of experience with SR and radiologists new to SR must perform, and estimated how quickly the new ...
Koivikko Mika P., Kauppinen Tomi A., Koivikko Mika P., Kauppinen Tomi A.   +3 more
openaire   +2 more sources

Machine-Learning-Based Side-Channel Evaluation of Elliptic-Curve Cryptographic FPGA Processor [PDF]

, 2018
Security of embedded systems is the need of the hour. A mathematically secure algorithm runs on a cryptographic chip on these systems, but secret private data can be at risk due to side-channel leakage information.
Yinan Kong, Mehrabi, Mohamad, Anjum, Ashiq, Mohamad Ali Mehrabi, Mukhtar, Naila, Kong, Yinan, Ashiq Anjum, Mohamad Ali Mehrabi, Naila Mukhtar   +8 more
core   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source