Results 61 to 70 of about 1,437,192 (281)

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

Least Squares Optimization: From Theory to Practice

open access: yesRobotics, 2020
Nowadays, Nonlinear Least-Squares embodies the foundation of many Robotics and Computer Vision systems. The research community deeply investigated this topic in the last few years, and this resulted in the development of several open-source solvers to ...
Giorgio Grisetti   +5 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

Penerapan Partial Least Squares Pada Data Gingerol

open access: yesComTech, 2010
Multivariate calibration model aims to predict the expensive measures obtained by using the measures of a cheap and easy. There are several problems that often occur in the model calibration, among others, and multikolinear. To overcome these problems we
Margaretha Ohyver
doaj   +1 more source

A note on sparse least-squares regression [PDF]

open access: yes, 2013
We compute a \emph{sparse} solution to the classical least-squares problem $\min_x||A x -b||,$ where $A$ is an arbitrary matrix. We describe a novel algorithm for this sparse least-squares problem.
Boutsidis, Christos   +1 more
core  

Monotonic Properties of the Least Squares Mean

open access: yes, 2010
We settle an open problem of several years standing by showing that the least-squares mean for positive definite matrices is monotone for the usual (Loewner) order.
Lawson, Jimmie, Lim, Yongdo
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

open access: yesMolecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung   +17 more
wiley   +1 more source

Total Least Squares Registration of 3D Surfaces

open access: yesInternational Journal of Environment and Geoinformatics, 2015
Co-registration of point clouds of partially scanned objects is the first step of the 3D modeling workflow. The aim of co-registration is to merge the overlapping point clouds by estimating the spatial transformation parameters.
Umut Aydar, M. Orhan Altan
doaj   +1 more source

Least-Squares Contour Alignment [PDF]

open access: yesIEEE Signal Processing Letters, 2009
The contour alignment problem, considered in this letter, is to compute the minimal distance in a least-squares sense, between two explicitly represented contours, specified by corresponding points, after arbitrary rotation, scaling, and translation of one of the contours.
Markovsky, Ivan, Mahmoodi, Sasan
openaire   +3 more sources

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

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