Results 71 to 80 of about 3,165,100 (264)

Least-squares methods for identifying biochemical regulatory networks from noisy measurements [PDF]

, 2007
<b>Background</b>: We consider the problem of identifying the dynamic interactions in biochemical networks from noisy experimental data.
Postlethwaite, I., Kwang-Hyun Cho, Kim, Jongrae, Heslop-Harrison, P., Heslop-Harrison, Pat, Postlethwaite, I, Bates, D.G., Cho, Kwang-Hyun, Postlethwaite, Ian, Declan G Bates, Bates, DG, Kim, J, Kim, J., Ian Postlethwaite, Cho, K-H., Jongrae Kim, Pat Heslop-Harrison, Bates, Declan, Heslop-Harrison, P, Postlethwaite Ian, Cho Kwang-Hyun, Bates Declan G, Kim Jongrae, Heslop-Harrison Pat   +23 more
core   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Consistent least squares fitting of ellipsoids

, 2004
A parameter estimation problem for ellipsoid fitting in the presence of measurement errors is considered. The ordinary least squares estimator is inconsistent, and due to the nonlinearity of the model, the orthogonal regression estimator is inconsistent ...
Van Huffel, S., Kukush, A., Markovsky, I.   +2 more
core   +1 more source

A robust partial least squares method with applications [PDF]

, 2007
Partial least squares regression (PLS) is a linear regression technique developed to relate many regressors to one or several response variables. Robust methods are introduced to reduce or remove the effect of outlying data points.
Romera, Rosario, González, Javier, Peña, Daniel   +2 more
core   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Consistency of the structured total least squares estimator in a multivariate errors-in-variables model

, 2005
The structured total least squares estimator, defined via a constrained optimization problem, is a generalization of the total least squares estimator when the data matrix and the applied correction satisfy given structural constraints.
Van Huffel, S., Kukush, A., Markovsky, I.   +2 more
core   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Least Squares Problems with Absolute Quadratic Constraints

Journal of Applied Mathematics, 2012
This paper analyzes linear least squares problems with absolute quadratic constraints. We develop a generalized theory following Bookstein's conic-fitting and Fitzgibbon's direct ellipse-specific fitting.
R. Schöne, T. Hanning
doaj   +1 more source