Results 71 to 80 of about 12,710,147 (277)

Physical quality of an Oxisol cultivated with maize submited to cover crops in the pre-cropping period Qualidade física de um Latossolo vermelho cultivado com milho submetido a culturas de plantas de cobertura em pré-safra

Revista Brasileira de Ciência do Solo, 2010
The intensive use of land alters the distribution of the pore size which imparts consequences on the soil physical quality. The Least Limiting Water Range (LLWR) allows for the visualization of the effects of management systems upon either the ...
Fabiana de Souza Pereira, Itamar Andrioli, Amauri Nelson Beutler, Cinara Xavier de Almeida, Faber de Souza Pereira   +4 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Soil properties of samples used to describe the soil water retention and soil resistance to penetration curves and the least limiting water range (n = 600).

, 2016
Soil properties of samples used to describe the soil water retention and soil resistance to penetration curves and the least limiting water range (n = 600).
Cássio A. Tormena (2552734), Alvaro Pires da Silva (2621980), Pablo J. Ghiberto (2621974), Miguel A. Pilatti (2621977), Silvia Imhoff (2621968), Paulo L. Libardi (2621971)   +5 more
core   +1 more source

Intervalo hídrico ótimo na avaliação de sistemas de pastejo contínuo e rotacionado Least limiting water range in the evaluation of continuous and short-duration grazing systems

Revista Brasileira de Ciência do Solo, 2004
A qualidade física do solo sob sistemas de pastejo contínuo e rotacionado foi avaliada pelo Intervalo Hídrico Ótimo (IHO). A amostragem foi realizada na área experimental da Embrapa Gado de Corte. Foi estudado um Latossolo Vermelho distrófico.
T. P. Leão, A. P. Silva, M. C. M. Macedo, S. Imhoff, V. P. B. Euclides   +4 more
doaj   +1 more source

Least limiting water range for different soil management practices in dryland farming in Iran

Archives of Agronomy and Soil Science, 2017
Integrated evaluation of soil physical properties using the least limiting water range (LLWR) approach may allow a better knowledge of soil water availability. We determined the LLWR for four tillage practices consisted of conventional tillage (CT), reduced tillage (RT), no-tillage (NT) and fallow no-tillage (NTf).
Fereshte Haghighi Fashi, Manouchehr Gorji, Forood Sharifi   +2 more
openaire   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Intervalo hídrico ótimo em um latossolo vermelho distroférrico sob diferentes sistemas de produção Least limiting water range in a distroferric red latossol under different growing systems

Engenharia Agrícola, 2008
Este trabalho teve o objetivo de caracterizar sistemas de cultivo quanto à qualidade estrutural do solo para o desenvolvimento de plantas por meio da determinação do Intervalo Hídrico Ótimo (IHO).
Milson E. Serafim, Antônio C. T. Vitorino, Paula P. P. Peixoto, Cristiano M. A. Souza, Daniel F. de Carvalho   +4 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source