Results 61 to 70 of about 12,710,147 (277)

Least limiting water range for oil palm production in Amazon region, Brazil

, 2017
In areas cultivated with oil palm, typically mechanized field operations using heavy vehicles may negatively affect soil physical properties and productivity. The aim of this study was to evaluate soil physical quality in an area cultivated with oil palm
Sueli Rodrigues (4656898), Raphael Leone da Cruz Ferreira (12793093), Herdjania Veras de Lima (12793090), Álvaro Pires da Silva (10442545), Michel Keisuke Sato (12793087)   +4 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Estimate of the least limiting water range based on relative density of an oxisol in Brazil

African Journal of Agricultural Research, 2016
The no-tillage technique has been expanding in the Brazilian Cerrado (savanna), but due to the rapid decomposition of residues and few options for profitable rotation crops, soil compaction can be a problem, seriously reducing water availability to plants.
Tomaz Ramos Fabricio, Carlos de Souza Maia Jo atilde o, L uacute cia dos Santos Weber Oscarlina, Holanda Campelo J uacute nior Jos eacute   +3 more
openaire   +2 more sources

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Assessing the physical quality of subsoiled cohesive horizons for Eucalyptus plantation

Acta Scientiarum. Agronomy
In Brazil, Eucalyptus plantations occupy approximately 7.6 million hectares, of which 8% are located in the state of Bahia. In southern Bahia, these plantations are predominantly established on soils with cohesive horizons, characterized by high soil ...
Frederico Alfenas Silva Valente Paes, Mateus de Paula Gomes, Flávio Souza Santos, Genelício Cruzoé Rocha   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Compactação do solo e intervalo hídrico ótimo na produtividade de arroz de sequeiro Soil compaction and least limiting water range in dryland rice yield

Pesquisa Agropecuária Brasileira, 2004
O objetivo deste trabalho foi determinar o intervalo hídrico ótimo e sua relação com a produtividade de grãos de arroz de sequeiro em um Latossolo Vermelho de textura média.
Amauri Nelson Beutler, José Frederico Centurion, Alvaro Pires da Silva, Cassiano Garcia Roque, Marcos Vieira Ferraz   +4 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Rendimento da soja e intervalo hídrico ótimo em latossolo vermelho sob plantio direto escarificado Soybean grain yield and least limiting water range in an oxisol under chiseled no-tillage

Revista Brasileira de Ciência do Solo, 2007
O intervalo hídrico ótimo (IHO) é um método que integra vários fatores que afetam o desenvolvimento das plantas, e corresponde ao intervalo de umidade do solo no qual não ocorre restrição de aeração (porosidade de aeração mínima de 0,10 m³ m-3) nem de ...
Vilson Antonio Klein, Rodrigo Kurylo Camara   +1 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source