Results 161 to 170 of about 11,858,600 (367)
Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge +18 morewiley +1 more sourceA synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote +8 morewiley +1 more sourceAdaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch +16 morewiley +1 more sourcePatient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert +16 morewiley +1 more sourceEffect of compost and chemical fertilizers on microbial biomass phosphorus. (T1: control; T2: 100% RDF; T3: enriched compost; T4: 100% RDF + enriched compost; T5: 50% RDF + enriched compost). * The least significant difference test for separation of means indicates that means that are separated by the same letter are not significantly distinct at P = 0.05.
Dilkhush Meena (21473985), Murli Dhar Meena (18864501), Satendra Singh Sengar (21473988), Vidhya Nand Mishra (21473991), Anup Kumar (1391461), Mohan Lal Lakhera (21473994), Mohan Lal Dotaniya (9727737), Mukesh Kumar Meena (11287133), Sujith Kumar (21473997), Bheeru Lal Meena (18864513), Ram Swaroop Jat (18864504), Lalit Krishan Meena (21474000), Mukesh Prajapat (21474003), Hari Singh Meena (18864510), Avijit Ghosh (1428496), Vasudev Meena (14312365), Pramod Kumar Rai (18864516), Parvender Sheoran (14703865), Vijay Singh Meena (20564213) +18 moreopenalex +1 more sourcePredictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman +17 morewiley +1 more sourceChanges in total-P, inorganic-P and organic-P fractions as affected with compost and chemical fertilizers. (T1: control; T2: 100% RDF; T3: enriched compost; T4: 100% RDF + enriched compost; T5: 50% RDF + enriched compost). * The least significant difference test for separation of means indicates that means that are separated by the same letter are not significantly distinct at P = 0.05.
Dilkhush Meena (21473985), Murli Dhar Meena (18864501), Satendra Singh Sengar (21473988), Vidhya Nand Mishra (21473991), Anup Kumar (1391461), Mohan Lal Lakhera (21473994), Mohan Lal Dotaniya (9727737), Mukesh Kumar Meena (11287133), Sujith Kumar (21473997), Bheeru Lal Meena (18864513), Ram Swaroop Jat (18864504), Lalit Krishan Meena (21474000), Mukesh Prajapat (21474003), Hari Singh Meena (18864510), Avijit Ghosh (1428496), Vasudev Meena (14312365), Pramod Kumar Rai (18864516), Parvender Sheoran (14703865), Vijay Singh Meena (20564213) +18 moreopenalex +1 more source
