Results 121 to 130 of about 10,133,028 (343)

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

open access: yesFEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Identification and characterization of a gene conferring stress resistance in Escherichia coli and cyanobacteria

open access: yesFEBS Open Bio, EarlyView.
Functional screening identified PcSyn14890, a cyanobacteria‐specific protein that enhances growth and stress resistance in E. coli and Synechocystis PCC6803. Although we expected it to function as a molecular chaperone, it was unable to protect against thermal aggregation of GAPDH.
Akiyo Yamada   +7 more
wiley   +1 more source

Research on the sensor calibration of pressure transmitter based on the least square method

open access: yes, 2014
The accuracy of capacitance pressure sensor is easily disturbed by work environment. In order to improve the accuracy of pressure sensor, the paper researches on the sensor calibration of pressure transmitter based on the least square method.
Yan BJ(闫炳均)   +4 more
core  

Least Square Polynomial Spline Approximations [PDF]

open access: yes, 1972
Bounds are derived for both the L2- and L∞-norms of the error in approximating sufficiently smooth functions by polynomial splines using an integral least square technique based on the theory of orthogonal projection in real Hilbert space.
Patent, Paul David, Paul D. Patent
core   +1 more source

Gender and poverty in South African rural areas

open access: yesCogent Social Sciences, 2019
In this article, we elicit the effects of gender on poverty reduction efforts in South Africa. Gender plays a huge role in the household decision-making process, as a result, it can determine if whether the household falls into a poverty trap or falls ...
Priviledge Cheteni   +2 more
doaj   +1 more source

Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants. ABSTRACT Objective Return of disease activity is expected when patients discontinue disease‐modifying therapy (DMT) for multiple sclerosis (MS). Some MS DMTs are associated with higher‐than‐expected disease activity (rebound) after discontinuation.
Ralf Gold   +12 more
wiley   +1 more source

Solving the Least Squares Method problem in the AHP for 3 X 3 and 4 X 4 matrices [PDF]

open access: yes, 2005
The Analytic Hierarchy Process (AHP) is one of the most popular methods used in Multi-Attribute Decision Making. The Eigenvector Method (EM) and some distance minimizing methods such as the Least Squares Method (LSM) are of the possible tools for ...
Bozóki, Sándor
core   +1 more source

SPG4 and Dementia: Expanding the Clinical Spectrum

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza   +19 more
wiley   +1 more source

Clinical Outcomes of SEEG‐Guided Radiofrequency Thermocoagulation in Children With Focal Drug‐Resistant Epilepsy: A Multicenter Real‐World Study

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stereoelectroencephalography‐guided radiofrequency thermocoagulation (SEEG‐RFTC) has emerged as a safe and effective minimally invasive treatment for children with drug‐resistant focal epilepsy. Although evidence from real‐world studies remains limited, numerous pediatric cases have demonstrated promising outcomes. This retrospective
Weitao Chen   +7 more
wiley   +1 more source

Least-square mean and standard error of semen quality traits of different INCENP haplotype combinations in Chinese Holstein bulls.

open access: yes, 2016
Least-square mean and standard error of semen quality traits of different INCENP haplotype combinations in Chinese Holstein bulls.
Qiang Jiang (764314)   +9 more
core   +1 more source

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