Results 51 to 60 of about 3,168,199 (247)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
On the computation of the structured total least squares estimator
, 2004 A class of structured total least squares problems is considered, in which the extended data matrix is partitioned into blocks and each of the blocks is (block) Toeplitz/Hankel structured, unstructured, or noise free.
Van Huffel, S. +2 more
core +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
Total Least Squares Registration of 3D Surfaces
International Journal of Environment and Geoinformatics, 2015 Co-registration of point clouds of partially scanned objects is the first step of the 3D modeling workflow. The aim of co-registration is to merge the overlapping point clouds by estimating the spatial transformation parameters.
Umut Aydar, M. Orhan Altan
doaj +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Penerapan Partial Least Squares Pada Data Gingerol
ComTech, 2010 Multivariate calibration model aims to predict the expensive measures obtained by using the measures of a cheap and easy. There are several problems that often occur in the model calibration, among others, and multikolinear. To overcome these problems we
Margaretha Ohyver
doaj +1 more source
Local Regularization Assisted Orthogonal Least Squares Regression
, 2006 A locally regularized orthogonal least squares (LROLS) algorithm is proposed for constructing parsimonious or sparse regression models that generalize well.
Chen, S.
core +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Least-squares methods for identifying biochemical regulatory networks from noisy measurements [PDF]
, 2007 <b>Background</b>: We consider the problem of identifying the dynamic interactions in biochemical networks from noisy experimental data.
Postlethwaite, I. +23 more
core +1 more source