Results 121 to 130 of about 3,586,130 (307)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Maternal employment, breastfeeding, and health: Evidence from maternity leave mandates [PDF]
Public health agencies around the world have renewed efforts to increase the incidence and duration of breastfeeding. Maternity leave mandates present an economic policy that could help achieve these goals.
Kevin S. Milligan, Michael Baker
core
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
BMC Public HealthBackground Breastfeeding provides multiple maternal and child benefits, but breastfeeding rates are suboptimal. Parental leave access and use have been associated with higher breastfeeding rates, however, there have been a lack of studies examining ...
John James Parker +2 more
doaj +1 more source
Part-time sick leave as a treatment method for individuals with musculoskeletal disorders [PDF]
There is increasing evidence that staying active is an important part of a recovery process for individuals on sick leave due to musculoskeletal disorders (MSDs). It has been suggested that using part-time sick-leave rather than full-time sick leave will
Andrén, Daniela, Svensson, Mikael
core
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
SAGE Open NursingObjective To explore the relationships between job satisfaction, work environment, and intention to leave among registered nurses in the United Arab Emirates (UAE), and to identify potential predictors of intention to leave.
Yousef Aljawarneh PhD, MSc, BSN, RN, FHEA +8 more
doaj +1 more source
Maximizing Productivity: Accommodations for Employees with Psychiatric Disablities [PDF]
, 2006 [Excerpt] Reasonable accommodations are adjustments to a work setting that make it possible for qualified employees with disabilities to perform the essential functions of their jobs.
Office of Disability Employment Policy
core +1 more source
Effect of Self-Interaction on Charged Black Hole Radiance
, 1994 We extend our previous analysis of the modification of the spectrum of black hole radiance due to the simplest and probably most quantitatively important back-reaction effect, that is self-gravitational interaction, to the case of charged holes.
Berger +7 more
core +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source