Results 121 to 130 of about 3,584,190 (305)

Sharp inflaton potentials and bi-spectra: Effects of smoothening the discontinuity

, 2014
Sharp shapes in the inflaton potentials often lead to short departures from slow roll which, in turn, result in deviations from scale invariance in the scalar power spectrum.
Hazra, Dhiraj Kumar, Martin, Jerome, Sriramkumar, L.   +2 more
core   +2 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Fathers’ work leave and infant breastfeeding in a state-representative sample of fathers in Georgia, United States

BMC Public Health
Background Breastfeeding provides multiple maternal and child benefits, but breastfeeding rates are suboptimal. Parental leave access and use have been associated with higher breastfeeding rates, however, there have been a lack of studies examining ...
John James Parker, Clarissa D. Simon, Craig F. Garfield   +2 more
doaj   +1 more source

Maternal employment, breastfeeding, and health: Evidence from maternity leave mandates [PDF]

Public health agencies around the world have renewed efforts to increase the incidence and duration of breastfeeding. Maternity leave mandates present an economic policy that could help achieve these goals.
Kevin S. Milligan, Michael Baker
core  

Time for a Change: The Case for LGBT-Inclusive Workplace Leave Laws and Nondiscrimination Protections [PDF]

, 2013
When Americans need time off work to recover from illness, bond with a new child, or care for a seriously ill family member, they often discover that their jobs provide little or no support.
Jared Make
core  

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Associations Between Intention to Leave, Job Satisfaction, and Work Environment Among Registered Nurses: A Cross-Sectional Study in the United Arab Emirates

SAGE Open Nursing
Objective To explore the relationships between job satisfaction, work environment, and intention to leave among registered nurses in the United Arab Emirates (UAE), and to identify potential predictors of intention to leave.
Yousef Aljawarneh PhD, MSc, BSN, RN, FHEA, Ahmad Al-Bashaireh PhD, MSc, BSN, RN, Nader E. Alotaibi PhD, Mariam Kawafha PhD, Osama Alkouri PhD, Tarfah Almesmari BSN, RN, Bashayer Alnuaimi BSN, RN, Sarah Alabdouli BSN, RN, Maryam Alsereidi BSN, RN   +8 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Maximizing Productivity: Accommodations for Employees with Psychiatric Disablities [PDF]

, 2006
[Excerpt] Reasonable accommodations are adjustments to a work setting that make it possible for qualified employees with disabilities to perform the essential functions of their jobs.
Office of Disability Employment Policy
core   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source