Results 161 to 170 of about 327,566 (304)

α2,3‐Sialyltransferase (ST3Gal1) regulates endometrioid‐type epithelial ovarian cancer cell migration and invasion via VEGF‐R2/JAK2/STAT3 signaling cascades

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To investigate the role of ST3 β‐galactoside α‐2,3‐sialyltransferase 1 (ST3Gal1) and vascular endothelial growth factor receptor 2 (VEGF‐R2) in endometrioid‐type epithelial ovarian cancer (E‐OC) because aberrant α2,3‐sialylation mediated by ST3Gal1 and VEGF‐R2‐related angiogenesis is linked with tumor progression. Methods ST3Gal1 and
Wei‐Ting Chao, Chia‐Hao Liu, Szu‐Ting Yang, Chen‐Hao Lin, Liang‐Wei Wang, Peng‐Hui Wang   +5 more
wiley   +1 more source

The T‐Cell Response Mechanism in Human Papillomavirus‐Associated Cervical Cancer and New Strategies for Immunotherapy

iNew Medicine, EarlyView.
ABSTRACT Human papillomavirus (HPV) is a double‐stranded DNA virus that infects human skin and mucosal tissues exclusively. The German scientist Harald zur Hausen was awarded the 2008 Nobel Prize in Physiology or Medicine for his discovery of the link between HPV infection and cervical cancer.
Fang Zhu, Farah Nazir, Ying Zhou, Yuhua Shang, Hongliang He, Tengchuan Jin   +5 more
wiley   +1 more source

Safety Assessment and Hypoglycemic Effect of Moringa oleifera Lam. Seed Lectin (WSMoL) in Alloxan‐Induced Diabetic Mice

Journal of Applied Toxicology, EarlyView.
ABSTRACT Moringa oleifera Lam. seeds contain WSMoL, a lectin previously studied for toxicity and pharmacological effects. In this study, we investigated WSMoL (10, 25, or 50 mg/kg i.p.) for acute and 14‐day repeated‐dose toxicity, as well as genotoxicity, in Swiss mice.
Alícia Natalie Silva dos Santos, Matheus Cavalcanti de Barros, Cleidiane Silva Vieira de Souza, Ryan Cristian da Silva, Luana Cassandra Breitenbach Barroso Coelho, Maria Tereza dos Santos Correia, Fernanda das Chagas Ângelo Mendes Tenório, Alisson Macário de Oliveira, Thiago Henrique Napoleão, Robson Raion de Vasconcelos Alves, Patrícia Maria Guedes Paiva   +10 more
wiley   +1 more source

Structural basis for carbohydrate recognition by the Gal/GalNAc lectin of Entamoeba histolytica involved in host cell adhesion. [PDF]

PLoS Pathog
Gérard SF, Redfield C, Higgins MK.
europepmc   +1 more source

Single‐Cell Profiling Identifies CLEC5A+ Macrophages as Key Drivers of Thoracic Aortic Aneurysm Via CCL5‐Mediated M1 Polarization

Journal of Clinical Laboratory Analysis, EarlyView.
Thoracic aortic aneurysm (TAA) is a life‐threatening cardiovascular disease with limited therapeutic options. Through single‐cell RNA sequencing of aortic tissues from healthy individuals and TAA patients (105,541 cells), we identified CLEC5A+macrophages as the predominant pathogenic cell population exhibiting the highest M1 polarization score. Machine
Xiangyu Li, Chunguang Guo, Mingyao Luo, Chang Shu   +3 more
wiley   +1 more source

Advances in the lectin pathway in systemic lupus erythematosus: from clinical correlations and mechanisms to targeted interventions. [PDF]

Inflamm Res
Feng R, Zhang Y, Chen Q, Wang Y, Tian Y, Xia Y.   +5 more
europepmc   +1 more source

Clinical Interpretation of Platelet Activation Marker sCLEC‐2 in Antiphospholipid Syndrome

Journal of Clinical Laboratory Analysis, EarlyView.
Soluble C‐type lectin‐like receptor 2 (sCLEC‐2), a marker of platelet activation, was evaluated in patients with antiphospholipid syndrome (APS). Plasma sCLEC‐2 levels and the sCLEC‐2/D‐dimer ratio were significantly elevated in APS compared with other collagen diseases and healthy controls.
Risa Kaneshige, Yukari Motoki, Kiyoshi Ichihara, Junzo Nojima   +3 more
wiley   +1 more source

Neurohumoral aspects of energy metabolism regulation

Терапевтический архив, 2004
Т Yu Demidova, A S Ametov, A V Selivanova   +2 more
doaj  

A potential histoplasmosis pathogenesis mechanism mediated by a lectin of Histoplasma capsulatum with affinity to β-galactose, favoring intravascular hemagglutination. [PDF]

PLoS Negl Trop Dis
Ramos-Martínez I, Flores-Robles E, Rodríguez-Arellanes G, Zenteno E, Pérez-Torres A, Taylor ML.   +5 more
europepmc   +1 more source

Association Between Multi‐Laboratory Parameters Pre‐ and Post‐Treatment and Pathological Features and Their Values in Clinical Decision in Primary Hepatic Carcinoma

Journal of Clinical Laboratory Analysis, EarlyView.
Primary hepatic cancer (PHC), especially hepatocellular carcinoma (HCC), is still a significant burden worldwide. The efficacy of diagnosis, treatment response monitoring, and prognostication using laboratory biomarkers is still a challenge. This study analyzed multi‐laboratory parameters pre‐ and post‐treatment and their associations with clinical and
Xiaowei Chi, Weifang Liu, Zihan Liu, Jie Liu   +3 more
wiley   +1 more source