Results 81 to 90 of about 3,190,451 (315)

Glomerular C4d Staining Does Not Exclude a C3 Glomerulopathy

Kidney International Reports, 2019
Introduction: C4d, an early product in the classical/lectin complement pathway has shown potential in the evaluation of C3 glomerulopathy where its absence would support an alternative pathway abnormality.
Geetika Singh, Shamresh Kumar Singh, Aasma Nalwa, Lavleen Singh, Immanuel Pradeep, Adarsh Barwad, Aditi Sinha, Pankaj Hari, Arvind Bagga, Soumita Bagchi, Sanjay Kumar Agarwal, Amit Kumar Dinda   +11 more
doaj   +1 more source

Information transfer in mammalian glycan-based communication

eLife, 2023
Glycan-binding proteins, so-called lectins, are exposed on mammalian cell surfaces and decipher the information encoded within glycans translating it into biochemical signal transduction pathways in the cell.
Felix F Fuchsberger, Dongyoon Kim, Natalia Baranova, Hanka Vrban, Marten Kagelmacher, Robert Wawrzinek, Christoph Rademacher   +6 more
doaj   +1 more source

Regulation of eosinophilia and allergic airway inflammation by the glycan-binding protein galectin-1 [PDF]

, 2016
Galectin-1 (Gal-1), a glycan-binding protein with broad antiinflammatory activities, functions as a proresolving mediator in autoimmune and chronic inflammatory disorders. However, its role in allergic airway inflammation has not yet been elucidated.
Abramoff, Ada G. Blidner, Amrita Rao, Boehme, Gabriel A. Rabinovich, Ge, Ha, He, Idil Bastan, Matsuura, P. Sriramarao, Rabinovich, Savita P. Rao, Sung Gil Ha, Xiao Na Ge, Yana G. Greenberg   +15 more
core   +1 more source

Lectin pathway proteins of the complement system in normotensive pregnancy and pre‐eclampsia

American Journal of Reproductive Immunology, 2019
The lectin pathway of the complement system may be involved in the pathogenesis of pre‐eclampsia. We aimed to investigate changes in serum concentrations of a broad range of lectin pathway proteins during normal pregnancy and their association with pre ...
J. Larsen, A. Andersen, C. Hvas, S. Thiel, M. Lassen, A. Hvas, A. T. Hansen   +6 more
semanticscholar   +1 more source

Collectin-11/MASP Complex Formation Triggers Activation of the Lectin Complement Pathway - The Fifth Lectin Pathway Initiation Complex [PDF]

Journal of Innate Immunity, 2012
Collectins and ficolins are important in the clearance of endogenous and exogenous danger materials. A new human collectin-11 was recently identified in low concentration in serum in complex with mannose-binding lectin (MBL)/ficolin-associated serine proteases. Collectin-11 binds to carbohydrate residues present on various microorganisms.
Ma, Ying Jie, Skjoedt, Mikkel-Ole, Garred, Peter   +2 more
openaire   +3 more sources

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

Progressive IgA Nephropathy Is Associated With Low Circulating Mannan-Binding Lectin–Associated Serine Protease-3 (MASP-3) and Increased Glomerular Factor H–Related Protein-5 (FHR5) Deposition

Kidney International Reports, 2018
IgA nephropathy (IgAN) is characterized by glomerular deposition of galactose-deficient IgA1 and complement proteins and leads to renal impairment. Complement deposition through the alternative and lectin activation pathways is associated with renal ...
Nicholas R. Medjeral-Thomas, Anne Troldborg, Nicholas Constantinou, Hannah J. Lomax-Browne, Annette G. Hansen, Michelle Willicombe, Charles D. Pusey, H. Terence Cook, Steffen Thiel, Matthew C. Pickering   +9 more
doaj   +1 more source

One‐Step Microfluidic Manufactured Fucose‐Decorated Sweetosomes Choose the Time and the Road for Their Intracellular Journey to Cancer Treatment

Advanced Healthcare Materials, EarlyView.
Sweetosomes, a new class of fucose‐decorated liposomes, are developed via a one‐step microfluidic process without surface chemistry. This study elucidates their main caveolae‐mediated entry and distinct endosomal trafficking. These nanostructures demonstrate superior endosomal escape, organelle acidity modulation, and prolonged plasma persistence ...
Mattia Tiboni, Mariele Montanari, Shiva Khorshid, Michele Verboni, Andrea Duranti, Simone Lucarini, Daniele Lopez, Annalisa Aluigi, Gianluca Morganti, Michele Menotta, Giovanna Panza, Daniel J. Klionsky, Barbara Canonico, Luca Casettari   +13 more
wiley   +1 more source

Potential immunosuppressive effects of Escherichia coli O157:H7 experimental infection on the bovine host [PDF]

, 2016
Background: Enterohaemorrhagic Escherichia coli (EHEC), like E. coli O157:H7 are frequently detected in bovine faecal samples at slaughter. Cattle do not show clinical symptoms upon infection, but for humans the consequences after consuming contaminated ...
Cox, Eric, Kieckens, Evelien, Li, RW, Rybarczyk, Joanna, Vanrompay, Daisy   +4 more
core   +1 more source

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source