Results 41 to 50 of about 3,626 (233)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Comparison of leeching and heparin therapy in management of acute venous congestion of limbs in rat

Pharmaceutical and Biomedical Research, 2016
Acute venous congestion leads to blood stasis in the tissue and impaired blood perfusion. Using medicinal leech is an old method for reducing tissue congestion.
Seyed Abdollah Mousavi, Maryam Ghasemi, Seyed Jaber Mousavi, Seyyed Saied Mousavi Darka, Vafa Bagheri   +4 more
doaj  

LEECH THERAPY IN TREATMENT OF CARDIOVASCULAR DISEASES

Ekologiya cheloveka (Human Ecology), 2015
The aim of this review was to summarize the evidence on the effectiveness of Leech therapy in treatment of cardiovascuLar diseases. This assessment is based on the analysis of results of clinical trials conducted in 2000-2015 and published in peer-reviewed literature indexed in PubMed, ISI Web of Science, Scopus, E-library.ru and E-library.kz databases.
Konyrtaeva N.N., Grjibovski A.M., Kausova G.K., Zhernov V.A., Kalmataeva Zh.A.   +4 more
openaire   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Leech as a lifeboat: Reminiscent role in plastic and reconstructive surgery!

TNOA Journal of Ophthalmic Science and Research, 2019
Leeching was a popular therapeutic practice since ancient times for various diseases. Previously, it was used as an unscientific home remedy by traditional therapists.
Rohan Dilip Newadkar, Ujwala Rohan Newadkar   +1 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Development of Leech extract as a therapeutic agent: A chronological review

Pharmacological Research - Modern Chinese Medicine
Introduction: Leech extract contains many identified bioactive substances which have a variety of biological effects. Leech extract was discovered in the late 19th century and since then many pharmaceutical products have been produced using leech extract
Mohamed Alaama, Omer Kucuk, Birdal Bilir, Ahmed Merzouk, Abbas Mohammad Ghawi, Mukerrem Betul Yerer, Mohamed Alaa Ahmado, Abdualrahman Mohammed Abdualkader, A.B.M. Helaluddin   +8 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Pigment reduction in nevus of Ota following leech therapy

Journal of Ayurveda and Integrative Medicine, 2014
Nevus of Ota is a congenital blue-gray color nevus afflicting unilaterally, the area near the eyes. It poses a huge cosmetic concern besides being a potential threat for developing melanoma sometime in the course of the disease. The treatment options are
Sanjeev Rastogi, Priyanka Chaudhari
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source