Results 1 to 10 of about 168 (126)

First Isolation of a Giant Virus from Wild Hirudo medicinalis Leech: Mimiviridae isolation in Hirudo medicinalis [PDF]

Viruses, 2013
Giant viruses and amoebae are common in freshwater, where they can coexist with other living multicellular organisms. We screened leeches from the species Hirudo medicinalis for giant viruses. We analyzed five H. medicinalis obtained from Tunisia (3) and
Mondher Boughalmi, Sarah Aherfi, Philippe Colson   +2 more
exaly   +5 more sources

Morganella Morganii Infection in Hirudo Medicinalis (Iran): A Case Report

Veterinary Sciences, 2022
Medicinal leeches (Hirudo medicinalis) are used in surgical and non-surgical manners. Morganella morganii is an opportunistic and zoonotic pathogenic bacterium causing serious clinical complications.
Hooman Rahmati-Holasoo, Iradj Ashrafi Tamai, Wolfram M Bruck   +2 more
exaly   +3 more sources

Unravelling the Extent of Diversity within the Iberian Medicinal Leeches (Hirudinea: Hirudo) Using Molecules and Morphology

Biology, 2021
Until the beginning of the 21st century, the famous medicinal leech was thought to be represented by only one species, Hirudo medicinalis. However, recent publications have demonstrated that under that name, at least five different species of medicinal ...
Andrés Arias, Victor Surugiu, Rafael Carballeira, Oana Paula Popa, Luis Ovidiu Popa, Serge Utevsky   +5 more
doaj   +1 more source

Draft genome sequences of Hirudo medicinalis and salivary transcriptome of three closely related medicinal leeches

BMC Genomics, 2020
Background Salivary cell secretion (SCS) plays a critical role in blood feeding by medicinal leeches, making them of use for certain medical purposes even today.
Vladislav V. Babenko, Oleg V. Podgorny, Valentin A. Manuvera, Artem S. Kasianov, Alexander I. Manolov, Ekaterina N. Grafskaia, Dmitriy A. Shirokov, Alexey S. Kurdyumov, Dmitriy V. Vinogradov, Anastasia S. Nikitina, Sergey I. Kovalchuk, Nickolay A. Anikanov, Ivan O. Butenko, Olga V. Pobeguts, Daria S. Matyushkina, Daria V. Rakitina, Elena S. Kostryukova, Victor G. Zgoda, Isolda P. Baskova, Vladimir M. Trukhan, Mikhail S. Gelfand, Vadim M. Govorun, Helgi B. Schiöth, Vassili N. Lazarev   +23 more
doaj   +1 more source

From haemadin to haemanorm: Synthesis and characterization of full‐length haemadin from the leech Haemadipsa sylvestris and of a novel bivalent, highly potent thrombin inhibitor (haemanorm)

Protein Science, Volume 32, Issue 12, December 2023., 2023
Abstract Hirudin from Hirudo medicinalis is a bivalent α‐Thrombin (αT) inhibitor, targeting the enzyme active site and exosite‐I, and is currently used in anticoagulant therapy along with its simplified analogue hirulog. Haemadin, a small protein (57 amino acids) isolated from the land‐living leech Haemadipsa sylvestris, selectively inhibits αT with a ...
Laura Acquasaliente, Andrea Pierangelini, Anna Pagotto, Nicola Pozzi, Vincenzo De Filippis   +4 more
wiley   +1 more source

Dysbiosis of intestinal homeostasis contribute to Whitmania pigra edema disease

Microbial Biotechnology, Volume 16, Issue 10, Page 1940-1956, October 2023., 2023
Workflow for the comprehensive exploration of IM dysbiosis in edema Whitmania pigra. Abstract Whitmania pigra is widely used in traditional Chinese medicine. However, W. pigra is being threatened by an edema disease with unknown causes (WPE). In this study, a comprehensive exploration of virome, microbiome, and metabolome aberrations in the intestine ...
Caijiao Dai, Xin Chen, Shiyu Qian, Yihui Fan, Lijuan Li, Junfa Yuan   +5 more
wiley   +1 more source

Hirudin inhibits glioma growth through mTOR‐regulated autophagy

Journal of Cellular and Molecular Medicine, Volume 27, Issue 18, Page 2701-2713, September 2023., 2023
Abstract Glioma is the most common primary malignant brain tumour, and survival is poor. Hirudin has anticancer pharmacological effects through suppression of glioma cell progression, but the molecular target and mechanism are poorly understood. In this study, we observed that hirudin dose‐ and time‐dependently inhibited glioma invasion, migration and ...
Ying Ma, Senbin Wu, Fanyi Zhao, Huifeng Li, Qiaohong Li, Jingzhi Zhang, Hua Li, Zhongmin Yuan   +7 more
wiley   +1 more source

The European medicinal leech Hirudo medicinalis L.: Morphology and occurrence of an endangered species

Zoosystematics and Evolution, 2014
Although the European medicinal leech (Hirudo medicinalis L. 1758) is one of the best-known members of the Hirudinea due to its use in phlebotomy, this species has been confused with the Mediterranean taxon H. verbana Carena 1820.
U. Kutschera, Joy Elliott
doaj   +1 more source

Interaction between nanomaterials and the innate immune system across evolution

Biological Reviews, Volume 98, Issue 3, Page 747-774, June 2023., 2023
ABSTRACT Interaction of engineered nanomaterials (ENMs) with the immune system mainly occurs with cells and molecules of innate immunity, which are present in interface tissues of living organisms. Immuno‐nanotoxicological studies aim at understanding if and when such interaction is inconsequential or may cause irreparable damage. Since innate immunity
Diana Boraschi, Laura Canesi, Damjana Drobne, Birgit Kemmerling, Annalisa Pinsino, Petra Prochazkova   +5 more
wiley   +1 more source

Leech presence on Iberian Brown Frog, Rana iberica, (Amphibia: Anura: Ranidae) from north-western Spain

Acta Herpetologica, 2008
The authors describe a case of parasitism on Rana iberica by two species of leeches, Batracobdella sp. and Hirudo medicinalis, in a mountainous area of north-western Spain. Conservation implications of high parasite load on small and isolated populations
César Ayres, Julian Comesaña Iglesias
doaj   +1 more source