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Comparative Study of Hirudins and Encoding Genes in Hirudo nipponia and Hirudo tianjinensis [PDF]

open access: yesBiology
This study systematically compared the genetic characteristics and functional activities of hirudins and their encoding genes between Hirudo nipponia (Hnip1–3) and Hirudo tianjinensis (Htia1–3) through bioinformatics analysis, recombinant protein ...
Jingjing Yin   +7 more
doaj   +5 more sources

Blood Relatives: Linking Evolutionary History and Conservation of Medicinal Leeches (Hirudo spp.) [PDF]

open access: yesEvolutionary Applications
Medicinal leeches of the genus Hirudo are both historically important in medicine and increasingly studied as models in ecology and biomedicine.
Gianluca Lombardo   +10 more
doaj   +3 more sources

Morganella Morganii Infection in Hirudo Medicinalis (Iran): A Case Report

open access: yesVeterinary Sciences, 2022
Medicinal leeches (Hirudo medicinalis) are used in surgical and non-surgical manners. Morganella morganii is an opportunistic and zoonotic pathogenic bacterium causing serious clinical complications.
W M Bruck, Babak Pakbin
exaly   +4 more sources

A new species of medicinal leech in the genus Hirudo Linnaeus, 1758 (Hirudiniformes, Hirudinidae) from Tianjin City, China [PDF]

open access: yesZooKeys, 2022
Medicinal leeches in the genus Hirudo have been utilized for therapeutic procedures for thousands of years. To date, six known species of Hirudo are widely distributed in different regions of the Eurasian continent.
Hao Wang   +5 more
doaj   +4 more sources

Research on ACEI of Low-Molecular-Weight Peptides from Hirudo nipponia Whitman

open access: yesMolecules, 2022
The renin-angiotensin system (RAS) is the primary pathway for regulating blood pressure in the body, and angiotensin-converting enzymes (ACEs) play a crucial role in it.
Zhao Ding, Keli Chen, Yunzhong Chen
doaj   +2 more sources

Unravelling the Extent of Diversity within the Iberian Medicinal Leeches (Hirudinea: Hirudo) Using Molecules and Morphology

open access: yesBiology, 2021
Until the beginning of the 21st century, the famous medicinal leech was thought to be represented by only one species, Hirudo medicinalis. However, recent publications have demonstrated that under that name, at least five different species of medicinal ...
Andrés Arias   +5 more
doaj   +2 more sources

Cloning, characterization, and heterologous expression of a candidate Hirudin gene from the salivary gland transcriptome of Hirudo nipponia

open access: yesScientific Reports, 2023
Hirudin is a pharmacologically active substance in leeches with potent blood anticoagulation properties. Although recombinant hirudin production isolated from Hirudo medicinalis Linnaeus and Hirudinaria manillensis Lesson is known, to our knowledge, this
Ping Shi   +5 more
doaj   +2 more sources

On the occurrence of the Dragon leech Hirudo troctina Johnson, 1816 (Annelida, Hirudinea) in Sardinia (Italy)

open access: yesThe European Zoological Journal
In recent decades, medicinal leeches of the genus Hirudo have experienced a sharp decline throughout their distribution range due to their overexploitation for medical use and habitat alteration.
F. Marrone   +5 more
doaj   +2 more sources

Diversity of hirudin and hirudin-like factor genes in the North-African medicinal leech, Hirudo troctina. [PDF]

open access: yesParasitol Res
Medicinal leeches of the genus Hirudo inhabit large areas of the Palaearctic realm. The distribution range of Hirudo troctina includes the southern Iberian peninsula and the northwestern regions of Africa. H.
Ahmed RB, Abilov A, Müller C.
europepmc   +2 more sources

Hirudo extract ameliorates proliferative vitreoretinopathy by promoting autophagy and attenuating the THBS2/PI3K/Akt pathway [PDF]

open access: yesScientific Reports
Epithelial‒mesenchymal transition (EMT) in retinal pigment epithelial (RPE) cells is believed to play a key role in the pathogenesis of proliferative vitreoretinopathy (PVR).
Hui Huang   +4 more
doaj   +2 more sources

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