Results 41 to 50 of about 4,705 (204)

The Hirudo Medicinalis Microbiome Is a Source of New Antimicrobial Peptides

International Journal of Molecular Sciences, 2020
Antimicrobial peptides (AMPs) are considered a promising new class of anti-infectious agents. This study reports new antimicrobial peptides derived from the Hirudo medicinalis microbiome identified by a computational analysis method applied to the H ...
E. Grafskaia, E. Pavlova, V. Babenko, I. Latsis, Maja Malakhova, V. Lavrenova, P. Bashkirov, Dmitrii M Belousov, D. Klinov, V. Lazarev   +9 more
semanticscholar   +1 more source

Construction of a medicinal leech transcriptome database and its application to the identification of leech homologs of neural and innate immune genes

BMC Genomics, 2010
Background The medicinal leech, Hirudo medicinalis, is an important model system for the study of nervous system structure, function, development, regeneration and repair.
Wincker Patrick, Da Silva Corinne, Casavant Thomas, Scheetz Todd, Bafna Vineet, Soares Marcelo B, Edsall Lee, Gaasterland Terry, Macagno Eduardo R, Tasiemski Aurélie, Salzet Michel   +10 more
doaj   +1 more source

Comparative genomics of two Asian medicinal leeches Hirudo nipponia and Hirudo tianjinensis: With emphasis on antithrombotic genes and their corresponding proteins.

International Journal of Biological Macromolecules
Leeches secrete various biologically active substances which have important medical and pharmaceutical values in antithrombotic treatments. Here, we provide a high quality genome of two Asian medicinal leeches Hirudo nipponia and Hirudo tianjinensis ...
Fang Zhao, Zuhao Huang, Bo He, Kaiqing Liu, Junyu Li, Zichao Liu, Gonghua Lin   +6 more
semanticscholar   +1 more source

Evaluation of per- and polyfluoroalkyl substances (PFAS) toxic effects on the acute inflammatory response in the medicinal leech Hirudo verbana.

Chemosphere
Per- and polyfluoroalkyl (PFAS) substances are a large group of chemicals with elevated water and oil-resistance properties, widely implicated in various applicative fields.
A. Calisi, N. Baranzini, G. Marcolli, C. Bon, D. Rotondo, D. Gualandris, L. Pulze, A. Grimaldi, F. Dondero   +8 more
semanticscholar   +1 more source

Bioactive Natural Products in Cardiovascular Disease: Focus on Thrombotic Events

Phytotherapy Research, EarlyView.
An overview of the role of natural products (NP) in cardiovascular disease prevention, highlighting key mechanisms of action: including antiplatelet, antithrombotic, anti‐inflammatory, and antioxidant effects. Additionally, it illustrates the integration of diet–drug interactions, nutritional epigenetics, and the role of artificial intelligence in ...
Maria Nektaria Magkoulia, Despoina Pantazi   +1 more
wiley   +1 more source

Effect of consuming blood-substitute feed on the transcriptome of the medicinal leech, Hirudo orientalis Utevsky and Trontelj, 2005 (Clitellata: Hirudinida) [PDF]

Caspian Journal of Environmental Sciences
While leeches in the genus Hirudo have long been models for neurobiology, the molecular underpinnings of nervous system structure and function in this group remain largely unknown.
Abbas Torabian, Majidreza Khoshkholgh, Sajad Nazari   +2 more
doaj   +1 more source

Hirudin Attenuates Uric Acid‐Induced Renal Tubular Injury via TNFRSF6B‐Mediated Suppression of NF‐κB Signaling

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
ABSTRACT Hyperuricemia, characterized by elevated serum uric acid (SUA) levels, is increasingly recognized as a pathological contributor to renal injury through oxidative stress, inflammation, and apoptosis. Hirudin, a thrombin inhibitor derived from leech saliva, has recently been noted for its anti‐inflammatory properties, yet its role in ...
Yingxue Zhao, Yongjie Qin, Lanzhi He, Haikun Luo, Ying Mo, Weihai Zhou, Huamei He, Ganping Zhou, Xihua Liu   +8 more
wiley   +1 more source

Leech presence on Iberian Brown Frog, Rana iberica, (Amphibia: Anura: Ranidae) from north-western Spain

Acta Herpetologica, 2008
The authors describe a case of parasitism on Rana iberica by two species of leeches, Batracobdella sp. and Hirudo medicinalis, in a mountainous area of north-western Spain. Conservation implications of high parasite load on small and isolated populations
César Ayres, Julian Comesaña Iglesias
doaj   +1 more source

Exploring the attachment of the Mediterranean medicinal leech (Hirudo verbana) to porous substrates

Journal of the Royal Society Interface, 2020
Haematophagous ectoparasites must ensure a reliable hold to their host during blood meals and, therefore, have evolved a broad spectrum of versatile and effective attachment mechanisms.
Tim Kampowski, Lara-Louise Thiemann, L. Kürner, T. Speck, S. Poppinga   +4 more
semanticscholar   +1 more source

Ethical and Frugal Approaches to Animal Experimentation in Bioelectronics and Neural Engineering—An Invertebrate Renaissance?

Advanced Electronic Materials, Volume 12, Issue 14, 20 July 2026.
Invertebrates are the classic neuroscience models and should make a comeback. Invertebrate organisms can be a more ethical and cost‐effective way to move bioelectronics research forward more rapidly. ABSTRACT The accelerating development of bioelectronic neural interfaces has brought increased attention to ethical considerations surrounding in vivo ...
Eric Daniel Głowacki
wiley   +1 more source