Results 191 to 200 of about 73,380 (256)

Jumping in simulated lunar gravity with blood flow restriction as a potential exercise countermeasure: The acute physiological effects

open access: yesExperimental Physiology, EarlyView.
Abstract The present study examined the cardiovascular, metabolic, neuromuscular and perceptual effects of low‐intensity jumping in simulated lunar gravity (∼20% bodyweight) with blood flow restriction (BFR). Fourteen healthy adults (24 ± 4 years; 1.81 ± 0.06 m; 75 ± 12 kg) completed an incremental jumping test in simulated lunar gravity (9.5° head‐up ...
Patrick Swain   +6 more
wiley   +1 more source

Daily hot‐water immersion preserves altitude‐induced haemoglobin mass expansion following descent independent of erythropoietin

open access: yesExperimental Physiology, EarlyView.
Abstract High‐altitude exposure increases haemoglobin mass (Hbmass), a key determinant of arterial oxygen‐carrying capacity, but following descent this adaptation can regress toward baseline within 7 days. Long‐term heat acclimation has emerged as an alternative stimulus for Hbmass expansion; however, whether post‐altitude passive‐heat exposure can ...
Elliott J. Jenkins   +12 more
wiley   +1 more source

TMEM16A chloride channels in the female reproductive tract and their role in normal and dysfunctional pregnancy and labour

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend TMEM16A plays a pivotal role in setting the duration of the action potential plateau in human uterine smooth muscle. An increase in TMEM16A expression in labour underpins a lengthening of the plateau and this provides time for the contraction to become larger and longer, important for timely successful labour.
Helena C. Parkington   +4 more
wiley   +1 more source

Mitochondrial oxidative stress, calcium and dynamics in cardiac ischaemia‐reperfusion injury

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Heart attack causes ischaemia–reperfusion injury in cardiomyocytes. Mitochondria generate reactive oxygen species (ROS), leading to oxidative stress. High levels of mitochondrial calcium (Ca2+) activate the mitochondrial permeability transition pore (mPTP), and excess ROS levels can lower the Ca2+ required to activate the mPTP ...
Emily Rozich   +5 more
wiley   +1 more source

Neuromuscular fatigability with repeated exercise in hypoxia: From single‐joint paradigms to sprints

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Acute hypobaric or normobaric hypoxic exposure accelerates neuromuscular fatigability during repeated exercise. Indices of peripheral and central fatigue are not different at exhaustion in mild, moderate and severe hypoxia compared with normoxia, but task failure occurs earlier.
Luca Ruggiero   +5 more
wiley   +1 more source

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