Results 81 to 90 of about 2,090,027 (300)

SemanticST: A Scalable Multi‐Contextual Graph Learning Framework for Uncovering Spatial Niches and Robust Multi‐Sample Integration in Spatial Transcriptomics

Advanced Science, EarlyView.
Technical limitations often let dominant signals overshadow rare cell types and fine‐grained heterogeneity in spatial transcriptomics. SemanticST, a graph neural network using multi‐semantic graph fusion and a novel min‐cut loss, recovers these subtle patterns.
Roxana Zahedi, Ahmadreza Argha, Nona Farbehi, Ivan Bakhshayeshi, Thantrira Porntaveetus, Youqiong Ye, Nigel H. Lovell, Hamid Alinejad‐Rokny   +7 more
wiley   +1 more source

MetaboSense: An Integrated Quantum Dot‐Mediated Aptamer Assay and Modular Microfluidic Platform for Continuous In‐Line Monitoring of Lung Metabolism During Ex Vivo Perfusion

Advanced Science, EarlyView.
MetaboSense is a first‐of‐its‐kind microfluidic platform enabling continuous, in‐line monitoring of glucose and lactate during ex vivo lung perfusion. Combining a quantum dot–mediated aptamer assay with mixing, depletion, and optofluidic detection modules, it achieves 60–s temporal resolution and shows strong agreement with standard blood gas analyzers,
Sanjana Srikant, Pouyan Keshavarz Motamed, Thomas Borrillo, Lielle Ronen, Gabriel Siebiger, Guillermo Garza, Hesam Abouali, Md Fahim Al Fattah, Ines Jaber, Dayan Ban, Marcelo Cypel, Mingyao Liu, Shaf Keshavjee, Andrew T. Sage, Mahla Poudineh   +14 more
wiley   +1 more source

Damage‐Free Passivation of Ambipolar OECTs with Fluoropolymer Film for Enhanced Performance and Stability Toward Reliable Biosignal Processing

Advanced Science, EarlyView.
A damage‐free iCVD fluoropolymer passivation strategy is introduced for ambipolar vertical OECTs. Vapor‐phase infiltration and thermal annealing induce nanoscale phase separation in the OMIEC channel, enhancing overall device performance. A single‐channel bipolar event‐driven spiking encoder is also demonstrated for electrocardiogram signal encoding ...
Junyeong Yang, Bohyun Lee, Hanna Lee, Mingyu Kim, Changsoon Choi, Jung Ah Lim, Youson Kim, Sung Gap Im   +7 more
wiley   +1 more source

Left superior vena cava draining into the left atrium, associated with partial anomalous pulmonary venous connection: surgical correction

, 2005
A persistent left superior vena cava draining into the left atrium may produce a symptomatic right-to-left shunt. Although intra-atrial rerouting techniques, in patients with no connecting vein, have proved to be reliable and successful, in many cases ...
Quarti A, Pierri MD, Di Eusanio G., DI EUSANIO, MARCO   +3 more
core   +1 more source

Phase Separation of TRIM21 Modulates PTPN14 Stability to Drive Flow‐Dependent Endothelial Activation and Atherogenesis

Advanced Science, EarlyView.
Disturbed flow promotes the formation of TRIM21‐rich biomolecular droplets, which concentrate TRIM21 and PTPN14 and facilitate their SPRY‐FERM interaction (illustrated by the TRIM21 D355‐PTPN14 R132 salt bridge). This condensate‐driven proximity enables TRIM21 to catalyze K48‐linked polyubiquitination of PTPN14 at lysine 956, leading to proteasome ...
Xue He, Qiannan Ma, Xue Wang, Jiaxu Mang, Chufeng Li, Bingjun Wu, Liu Yao, Yequn Chen, Qiankun Bao, Yi Zhu, Jinlong He   +10 more
wiley   +1 more source

Post prandial and nocturnal recurrent acute heart failure caused by a large hiatal hernia

Journal of Acute Disease, 2012
We report a case of left heart failure caused by a sliding hiatus hernia compressing on left atrium. A 95-year-old woman was admitted with recurrent episodes of shortness of breath and chest pain.
Abdurrahim Dusak
doaj   +1 more source

Percutaneous closure of a persistent left superior vena cava connected to the left atrium

, 2006
Cerebral emboli and abscesses are common complications in patients with cyanotic congenital heart disease and right-to-left shunt. Of those, a persistent left superior vena cava (LSVC) draining into the left atrium, directly or through an unroofed ...
Troost, Els, Budts, Werner, Gewillig, Marc   +2 more
core   +1 more source

SerpinA3 is an Endogenous TGF‐β Receptor Antagonist that Attenuates Cardiac Fibroblast Activation and Fibrotic Remodeling

Advanced Science, EarlyView.
SerpinA3 acts as an endogenous TGF‐β receptor antagonist that binds to the extracellular domain of TGFR‐1, thereby preventing TGFR‐1–TGFR‐2 complex formation. This receptor‐level blockade suppresses TGF‐β/Smad2/3 signaling, attenuates cardiac fibroblast activation, and extracellular matrix deposition, and ultimately alleviates pressure overload–induced
Hui Wang, Jieyu Cui, Chunlu Huang, Wanyi Guo, Tong Liu, Yi Zhu, Shuai Shao, Kangyin Chen, Jinlong He, Qiankun Bao   +9 more
wiley   +1 more source

Passive versus active right ventricular support during lung transplantation: Insights from a porcine pulmonary ischemia-reperfusion injury modelCentral MessagePerspective

JTCVS Techniques
Objectives: Bilateral lung transplantation might require venoarterial extracorporeal membrane oxygenation for intraoperative support. However, the impact of extracorporeal life support modalities on right ventricular function and pulmonary ischemia ...
Michaela Orlitová, PhD, Piet Claus, MSc, PhD, Dieter van Beersel, MD, Anna E. Kaiser-Frick, PhD, Arno Vanstapel, MD, PhD, Walter Coudyzer, MD, Kristof Van de Voorde, BC, Karlien Degezelle, MSc, Robin Vos, MD, PhD, Dirk E. Van Raemdonck, MD, PhD, Laurens J. Ceulemans, MD, PhD, Arne P. Neyrinck, MD, PhD, Tom Verbelen, MD, PhD   +12 more
doaj   +1 more source

Intracardiac mass: A rare case report

Journal of the Indian Academy of Echocardiography & Cardiovascular Imaging, 2017
Intracardiac thrombus is seen in many circumstances. Rarely it is found in left atrium in the absence of mitral stenosis. Here we are reporting a case of Cardiomyopathy with thrombus in left ventricle and left atrium.
S T Yavagal
doaj   +1 more source