Results 111 to 120 of about 2,526,322 (292)

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

Syntactic patterns of Italo-Romance CP-layers in Transformers, ChatGPT and Deepseek: two case studies from Romansh and Neapolitan

AI-Linguistica
Large-language models (LLMs) have recently become the object of syntactic investigation, whether via standard probability scores in masked modeling or the interaction with conversationalAI.
Giuseppe Samo, Angelapia Massaro
doaj   +1 more source

The Acquisition of the left Periphery in Bilingual French/German First Language Aquisition [PDF]

, 2005
In der vorliegenden Dissertation wird der Erwerb der linken Satzperipherie im Deutsch/Französisch bilingualen Erstspracherwerb untersucht. Schwerpunkt der Arbeit ist die Überprüfung der Hypothese von Platzack (2001), nach der die linke Satzperipherie ...
Bonnesen, Matthias
core  

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Evolution of Coats’ disease over a decade: A bilateral asymmetrical presentation

Indian Journal of Ophthalmology. Case Reports
A pre-teen presented to us with complaints of outward deviation of the left eye noted by the parents a few days before. On examination, the anterior segment examination was within normal limits in both eyes. Fundus evaluation showed extrafoveal exudative
Dinesh Talwar, Lalit Verma, Shweta Singh, Avnindra Gupta, Gauri Khare   +4 more
doaj   +1 more source

Cartography AND the Left Periphery OF the Clause in Igbo

Languages display certain constructions which typically involve peripheral positions in the clause. In this regard, the Igbo language provides a number of interesting evidences with respect to both empirical and theoretical issues.
Osuagwu, E. C. (Eunice)
core  

Topicalization, clld and the left periphery

, 2013
Starting from a consideration of the internal make-up of adverbial clauses this paper shows that the widespread assumption that fronted arguments in English and CLLD constituents in Romance occupy the same position leads to a number of problems.
Haegeman, Liliane M. V.
core